Antagonistic regulation of cyclin expression by the bZIP transcription factors Pcr1 and Atf1 during G2/M transition
| Autor: | Geetanjali Sundaram, Madhurima Paul, Sohini Basu, Elizabeth Das, Protiti Maiti Ghosh, Sushobhana Bandyopadhyay, Syed Benazir Alam |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cell cycle checkpoint Cyclin A Activating transcription factor Cyclin B Microbiology 03 medical and health sciences Gene Expression Regulation Fungal Schizosaccharomyces Genetics Phosphorylation Promoter Regions Genetic Molecular Biology Mitosis Transcription factor Activating Transcription Factor 1 biology ATF1 Cell growth fungi Cell Cycle Cell cycle Phosphoproteins Activating Transcription Factors Cell biology G2 Phase Cell Cycle Checkpoints 030104 developmental biology biology.protein Schizosaccharomyces pombe Proteins Mitogen-Activated Protein Kinases Cell Division |
| Zdroj: | FEMS microbiology letters. 364(14) |
| ISSN: | 1574-6968 |
| Popis: | The transcription factor Atf1 is known to promote cell survival during various stress conditions in Schizosaccharomyces pombe by activating the expression of appropriate genes. It can also activate transcription of other important genes responsible for cell cycle progression. An Atf1-dependent increase in the expression of cell division promoting genes will oppose activation of checkpoints necessary to ensure repairs and cell survival during stress. Hence, selective inhibition of the cell cycle-related functions of Atf1 would be indispensable for cellular survival during stress. Here we present evidence in favour of selective inhibition of Atf1's ability to activate cdc13+ transcription. We show that the transcription factor Pcr1 can specifically inhibit the recruitment of Atf1 on cdc13 promoter and thereby prevent Atf1-mediated mitotic acceleration. We also show that this opposition of Atf1 functions by Pcr1 extends to the G1-S transition event as well. Altogether these results suggest a previously unknown antagonistic function of Atf1 and Pcr1 in regulating Cdc13 expression during cell cycle progression. |
| Databáze: | OpenAIRE |
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