Anthracycline-induced cardiotoxicity in women without cardiovascular diseases: molecular and genetic predictors

Autor:	Sergey N Shilov, E V Grakova, Elena T Ratushnyak, Maria N Neupokoeva, Anna A Popova, A T Teplyakov, Ekaterina N Berezikova, K. V. Kopeva
Rok vydání:	2021
Předmět:	medicine.medical_specialty Chemotherapy Cardiotoxicity GPX1 NADPH oxidase biology business.industry medicine.medical_treatment SOD2 General Medicine medicine.disease Gastroenterology Exon Breast cancer Internal medicine biology.protein Medicine Cardiology and Cardiovascular Medicine business Gene
Zdroj:	Acta Cardiologica. 77:805-814
ISSN:	0373-7934 0001-5385
Popis:	OBJECTIVE To evaluate role of molecular (endothelin-1, soluble Fas-L, NT-proBNP, TNF-α, interleukin-1β,) and genetic factors (NOS3 (rs1799983), EDNRA (C + 70G, rs5335), NADPH oxidase (C242T, rs4673), p53 protein (polymorphic marker-Arg72Pro exon 4, rs1042522), NOS3 (Glu298Asp, rs1799983), Caspase 8 (CASP8, rs3834129 and rs1045485), interleukin-1β gene (Il-1β, rs1143634), TNF-α gene (rs1800629), SOD2 (rs4880), GPX1 (rs1050450) in development of anthracycline-induced cardiotoxicity (AIC) in women without cardiovascular diseases. METHODS A total of 176 women with breast cancer and without cardiovascular diseases who received anthracyclines were enrolled in the study. After the 12 months of chemotherapy (CT), all patients were divided into two groups: group 1 (n = 52) comprised patients with AIC, group 2 (n = 124) comprised those without it. RESULTS Based on ROC-analysis, levels of endothelin-1 of ≥9.0 pg/mL (AUC of 0.699), sFas-L of ≥98.3 ng/mL (AUC of 0.990), and NT-proBNP of ≥71.5 pg/mL (AUC of 0.994;) were identified as a cut-off values predicting AIC during 12 months after CT. Whereas, NT-proBNP and sFas-L were more significant predictors than endothelin-1 (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a0148840fa3ec658562de883a5adc0 https://doi.org/10.1080/00015385.2021.2003061 Zobrazit plný text záznamu