Salivary cortisol as a tool for physiological studies and diagnostic strategies
| Autor: | Sonir Roberto Rauber Antonini, L B Santiago, Paula Conde Lamparelli Elias, Margaret de Castro, Alexandre Moreira, Carlos Eduardo Martinelli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty endocrine system Adolescent Hydrocortisone Physiology Immunology Biophysics Cushing's syndrome Biochemistry Dexamethasone Internal medicine Obese group Humans Medicine Obesity Circadian rhythm General Pharmacology Toxicology and Pharmaceutics Saliva Cushing Syndrome Glucocorticoids lcsh:QH301-705.5 Salivary cortisol lcsh:R5-920 business.industry General Neuroscience Infant Newborn Infant Cell Biology General Medicine Circadian Rhythm salivary cortisol Endocrinology lcsh:Biology (General) ontogeny Free cortisol Female business lcsh:Medicine (General) Biomarkers hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Brazilian Journal of Medical and Biological Research v.33 n.10 2000 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Volume: 33, Issue: 10, Pages: 1171-1175, Published: OCT 2000 Brazilian Journal of Medical and Biological Research, Vol 33, Iss 10, Pp 1171-1175 (2000) ResearcherID |
| Popis: | Salivary cortisol is an index of plasma free cortisol and is obtained by a noninvasive procedure. We have been using salivary cortisol as a tool for physiological and diagnostic studies, among them the emergence of circadian rhythm in preterm and term infants. The salivary cortisol circadian rhythm in term and premature infants was established between 8 and 12 postnatal weeks. In the preterm infants the emergence of circadian rhythm was parallel to the onset of sleep rhythm. We also studied the use of salivary cortisol for screening for Cushing's syndrome (CS) in control and obese outpatients based on circadian rhythm and the overnight 1 mg dexamethasone (DEX) suppression test. Salivary cortisol was suppressed to less than 100 ng/dl after 1 mg DEX in control and obese patients. A single salivary cortisol measurement at 23:00 h and again after 1 mg DEX above the 90th percentile of the obese group values had sensitivity and specificity of 93 and 93% (23:00 h), and 91 and 94% (after DEX), respectively. The sensitivity improved to 100% when we combined both parameters. We also studied 11 CS children and 21 age-matched primary obese children for whom salivary cortisol sensitivity and specificity were 100/95% (23:00 h), and 100/95% (1 mg DEX), respectively. Similar to adults, sensitivity and specificity of 100% were obtained by combining 23:00 h and 1 mg DEX. The measurement of salivary cortisol is a useful tool for physiological studies and for the diagnosis of CS in children and adults on an outpatient basis. |
| Databáze: | OpenAIRE |
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