Effect of complete cardiac denervation on atrial natriuretic factor release in baboons
| Autor: | Elvio Covino, Eric A. Rose, Giuseppe Lembo, Antonio Panza, Mark L. Barr, Massimo Volpe, Craig R. Smith, S. Pignalosa, Mario Condorelli, Pepino P |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Central Venous Pressure medicine.medical_treatment Posture Blood Pressure Transplantation Autologous Atrial natriuretic peptide Heart Rate Internal medicine Medicine Animals business.industry Central venous pressure Systemic blood pressure Heart Denervation Pathophysiology Autotransplantation Cardiac nerve Endocrinology Cardiac denervation cardiovascular system Heart Transplantation Surgery business Atrial Natriuretic Factor Papio |
| Zdroj: | The Journal of surgical research. 53(1) |
| ISSN: | 0022-4804 |
| Popis: | We investigated the influence of cardiac innervation on atrial natriuretic factor (ANF) release in baboons. For this purpose, plasma ANF levels were measured in control conditions and in response to head-down (-45 degrees) and head-up tilt (+45 degrees) in six anesthetized baboons before and after complete cardiac denervation obtained by orthotopic autotransplantation of the heart. Cardiac denervation did not modify baseline plasma ANF levels (60.4 +/- 17 pg/ml before and 63.1 +/- 16 pg/ml after heart autotransplantation). In contrast the significant ANF responses to changes in central venous pressure (CVP) induced by postural maneuvers (-45 degrees, + 16.2 +/- 4 pg/ml; +45 degrees, -18.5 +/- 4 pg/ml) were markedly altered after cardiac denervation (-45 degrees, +5.8 +/- 2 pg/ml; +45 degrees, -7.6 +/- 1 pg/ml). The changes in CVP and systemic blood pressure evoked by the postural challenges were comparable before and after cardiac denervation. These results demonstrate that cardiac nerves play a role in the control of ANF release. |
| Databáze: | OpenAIRE |
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