CONTROVERSIES IN DRUG ALLERGY: TESTING FOR DELAYED REACTIONS
| Autor: | Andreas J. Bircher, Wen-Hung Chung, Luciana Kase Tanno, Jean-Claude Roujeau, Neil H. Shear, Jason A Trubiano, Paul L. Bigliardi, Rannakoe J. Lehloenya, Ana Dioun Broyles, Jonny Peter, Annick Barbaud, Rocco Luigi Valluzzi, Maja Mockenhaupt, Elizabeth J. Phillips, Yoon-Seok Chang, Munir Pirmohamed |
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| Přispěvatelé: | Gestionnaire, Hal Sorbonne Université, Vanderbilt University Medical Center [Nashville], Vanderbilt University [Nashville], University of Minnesota [Twin Cities] (UMN), University of Minnesota System, University of Basel (Unibas), Boston Children's Hospital, Harvard Medical School [Boston] (HMS), Seoul National University [Seoul] (SNU), University of Cape Town, University of Freiburg [Freiburg], University of Liverpool, Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), University of Toronto, Sunnybrook Health Sciences Center, CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), University of Melbourne, IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Service de dermatologie et allergologie [CHU Tenon], CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Interactions Gènes-Risques environnementaux et Effets sur la Santé (INGRES), Université de Lorraine (UL), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Drug
medicine.medical_specialty fixed drug eruption media_common.quotation_subject Immunology Drug allergy HLA-B15 Antigen acute generalized exanthematous pustulosis Southeast asian Article 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Asian People Drug tolerance Stevens-Johnson syndrome/toxic epidermal necrolysis drug reaction with eosinophilia and systemic symptoms medicine Immunology and Allergy Animals Humans patch [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology intradermal Exanthem media_common Skin Tests business.industry Delayed prick [SDV.MHEP.DERM] Life Sciences [q-bio]/Human health and pathology/Dermatology [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences Acute generalized exanthematous pustulosis medicine.disease Dermatology Toxic epidermal necrolysis Dideoxynucleosides 3. Good health HLA [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences Carbamazepine oral challenge 030228 respiratory system HLA-B Antigens Stevens-Johnson Syndrome business [SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology Adverse drug reaction |
| Zdroj: | Journal of Allergy and Clinical Immunology Journal of Allergy and Clinical Immunology, Elsevier, 2019, 143 (1), pp.66-73. ⟨10.1016/j.jaci.2018.10.030⟩ JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY |
| ISSN: | 0091-6749 |
| DOI: | 10.1016/j.jaci.2018.10.030⟩ |
| Popis: | International audience; Controversies exist with regard to in vivo approaches to delayed immunologically mediated adverse drug reactions, such as exanthem (maculopapular eruption), drug reaction with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, Stevens-Johnson syndrome/toxic epidermal necrolysis, and fixed drug eruptions. In particular, widespread differences exist between regions and practice on the availability and use of intradermal and patch testing, the standard drug concentrations used, the use of additional drugs in intradermal and patch testing to help determine cross-reactivity, the timing of testing in relation to the occurrence of the adverse drug reaction, the use of testing in specific phenotypes, and the use of oral challenge in conjunction with delayed intradermal and patch testing to ascertain drug tolerance. It was noted that there have been advances in the science of delayed T cell-mediated reactions that have shed light on immunopathogenesis and provided a mechanism of preprescription screening in the case of HLA-B*57:01 and abacavir hypersensitivity and HLA-B*15:02 and carbamazepine Stevens-Johnson syndrome/toxic epidermal necrolysis in Southeast Asian subjects. Future directions should include the collaboration of large international networks to develop and standardize in vivo diagnostic approaches, such as skin testing and patch testing, combined with ex vivo and in vitro laboratory approaches. |
| Databáze: | OpenAIRE |
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