Acute Heart Failure in the Elderly
| Autor: | Isaac Kobrin, Gadi Cotter, Dirk J. van Veldhuisen, Jill Ann El-Khorazaty, Maurizio Rainisio, Guillaume Jondeau, Henry Krum, Beth A. Davison, John R. Teerlink, John J.V. McMurray, Robert C. Bourge, John D. Parker, Christopher M. O'Connor, John G.F. Cleland, Marco Metra, Guillermo Torre-Amione, Olga Milo, Valentina Carubelli |
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| Přispěvatelé: | Cardiovascular Centre (CVC) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Prognostic variable medicine.medical_specialty ACUTE MYOCARDIAL-INFARCTION Respiratory rate medicine.drug_class TROPONIN ELEVATION RENAL DYSFUNCTION Heart failure Hemoglobin levels NATRIURETIC-PEPTIDE outcomes Double-Blind Method Internal medicine Atrial Fibrillation age Acute Disease Aged Aged 80 and over Female Heart Failure Hospitalization Humans Hypertension Middle Aged Mortality Prognosis Treatment Outcome 80 and over medicine Natriuretic peptide Myocardial infarction End point business.industry Atrial fibrillation ASSOCIATION medicine.disease HIGH-RISK HOSPITALIZATION Cardiology TRIAL RELAX-AHF Cardiology and Cardiovascular Medicine business TASK-FORCE |
| Zdroj: | JOURNAL OF CARDIAC FAILURE, 21(3), 179-188. Churchill Livingstone |
| ISSN: | 1071-9164 |
| Popis: | Background: Acute heart failure (HF) is common in the elderly, but the association of age with clinical outcomes and prognostic factors has not been examined thoroughly.Methods and Results: We analyzed the clinical and laboratory characteristics and the outcomes of 1,347 patients with acute HF enrolled in the VERITAS trial. Subjects were subdivided based on their median age of 72 years. Older patients had a higher prevalence of comorbidities and a higher prevalence of hypertension and atrial fibrillation. During a mean follow-up of 149 +/- 61 days, 432 patients (32.1%) reached the composite end point of death, in-hospital worsening HF, or HF rehospitalization by 30 days, and 135 patients (10.4%) died by 90 days, with a worse outcome in elderly patients in both cases. At multivariable analysis, different variables were related with each of these outcomes in elderly compared with younger patients. Regarding deaths at 90 days, plasma urea nitrogen and hemoglobin levels were predictive only in the younger patients, whereas respiratory rate and albumin levels were associated with mortality only in the older patients.Conclusions: Elderly patients with acute HF have different clinical characteristics and poorer outcomes. Prognostic variables differ in elderly compared with younger patients. |
| Databáze: | OpenAIRE |
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