Activity of platelet-activating factor (PAF) acetylhydrolase in plasma from healthy habitual cigarette smokers
| Autor: | Shigeru Takamatsu, Tadaatsu Imaizumi, Mutsu Takamatsu, M. Hiramoto, Masahiro Koyanagi, Hidemi Yoshida, Kei Satoh, Yoko Kawamura |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty PAF acetylhydrolase Apolipoprotein B Platelet Aggregation Arteriosclerosis Lipoproteins Phospholipases A chemistry.chemical_compound Internal medicine Total cholesterol medicine Humans Platelet Platelet Activating Factor PAF acetylhydrolase activity Aged Aged 80 and over Platelet-activating factor Triglyceride biology business.industry Smoking Mean age Middle Aged Endocrinology chemistry Phospholipases 1-Alkyl-2-acetylglycerophosphocholine Esterase biology.protein lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business |
| Zdroj: | Heart and vessels. 5(2) |
| ISSN: | 0910-8327 |
| Popis: | The activity of platelet-activating factor acetylhydrolase, a specific metabolizing enzyme of platelet-activating factor (PAF), in plasma of 39 male subjects was determined radiochemically by the method of Stafforini et al., (1987) J Biol Chem 262: 4223-4230, to clarify to what extent PAF affects atherosclerotic disorders induced by habitual smoking. The subjects examined included 18 habitual smokers (mean age: 62 +/- 10.6 years) and 21 age-matched nonsmokers. Plasma PAF acetylhydrolase activity was higher in the smokers than in the nonsmokers. There was no difference between smokers and nonsmokers in platelet aggregability in response to PAF or ADP. A higher apoprotein B/apoprotein A-I ratio in smokers as compared to nonsmokers was the only manifestation of abnormal lipoprotein metabolism in the former group. In the smokers, plasma PAF acetylhydrolase activity was directly proportional to total cholesterol, LDL-cholesterol, triglyceride, apoprotein B, LDL-cholesterol/HDL-cholesterol or apoprotein B/apoprotein A-I, and inversely proportional to HDL-cholesterol or apoprotein A-I. The results obtained suggest that alterations in PAF acetylhydrolase levels result from a slightly abnormal lipoprotein metabolism. Determination of plasma PAF acetylhydrolase activity is useful to study the role of PAF in atherosclerotic changes induced by smoking. |
| Databáze: | OpenAIRE |
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