Enzyme and gold catalysis: A new enantioselective entry into functionalized 4-hydroxy-2-pyrrolines

Autor:	Bas Ritzen, Laurens Brocken, Floris P. J. T. Rutjes, F.L. van Delft, Gaston J. J. Richelle
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Hydroxynitrile lyase Enzyme chemistry Organic Chemistry Enantioselective synthesis Hydrocyanation Organic chemistry Synthetic Organic Chemistry Catalysis
Zdroj:	Synlett, 25, 270-274 Synlett, 25, 2, pp. 270-274
ISSN:	0936-5214
Popis:	A new route toward functionalized pyrrolines starting from acetylenic aldehydes was developed. Key steps involved a ­hydroxynitrile lyase catalyzed asymmetric hydrocyanation of acetylenic aldehydes and a gold-catalyzed cyclization of substituted acetylene-containing amino alcohols.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4199ceac17d6997816b987c285c094ab https://hdl.handle.net/2066/128370 Zobrazit plný text záznamu