Cost-effectiveness of 13-valent pneumococcal conjugate vaccine: Germany, Greece, and The Netherlands
| Autor: | Raymond Farkouh, Sharon Hwang, David R. Strutton, Sotiria Papanicolaou, Stephanie R. Earnshaw, Rogier M. Klok, Stathis Kontodimas, Ulrike Theidel |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Microbiology (medical) Serotype Pediatrics medicine.medical_specialty Adolescent Acute otitis media Cost effectiveness Cost-Benefit Analysis complex mixtures Pneumococcal Infections Pneumococcal conjugate vaccine Pneumococcal Vaccines Young Adult Germany Epidemiology medicine Humans Child health care economics and organizations Aged Netherlands Aged 80 and over Models Statistical Greece Cost–benefit analysis business.industry Incidence (epidemiology) Infant Newborn Infant Middle Aged Cost savings Infectious Diseases Child Preschool Female business medicine.drug |
| Zdroj: | Journal of Infection. 64:54-67 |
| ISSN: | 0163-4453 |
| DOI: | 10.1016/j.jinf.2011.10.015 |
| Popis: | Summary Background Seven-valent pneumococcal conjugate vaccine (PCV7) had profound public-health impacts and is considered cost-effective and potentially cost saving. Two new PCVs have been launched, a 10-valent vaccine (PCV10) and a 13-valent vaccine (PCV13). We examined public-health and economic impacts of PCV pediatric national immunization programs (NIPs) in Germany, Greece, and the Netherlands. Methods A decision-analytic model was developed to estimate the impact of PCV13, PCV7, and 10-valent pneumococcal conjugate vaccine (PCV10) on invasive pneumococcal disease (IPD), pneumonia (PNE), and acute otitis media (AOM). Using epidemiological data, we calculated the cases of IPD, PNE, and AOM, using country-specific incidence, serotype coverage, disease sequelae, mortality, vaccine effectiveness, indirect effects, costs, and utilities. Direct effects for PCV13- and PCV10-covered serotypes were assumed similar to PCV7. PCV13 was assumed to confer an indirect effect, while PCV10 was not. Assumptions were tested in sensitivity analyses. Results In a NIP, PCV13 was estimated to eliminate 31.7%, 46.4%, and 33.8% of IPD in Germany, Greece, and the Netherlands, respectively. Compared with PCV7 and PCV10, PCV13 was found to be cost-effective or cost saving in all cases when PCV13 indirect effects were included. Conclusions Pediatric NIPs with PCV13 in Europe are expected to have dramatic public-health impacts and be cost-effective or cost saving. |
| Databáze: | OpenAIRE |
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