Synthesis and SAR study of novel 7-(pyridinium-3-yl)-carbonyl imidazo[5,1-b]thiazol-2-yl carbapenems
| Autor: | Katsuyoshi Iwamatsu, Yasuo Yamamoto, Takahisa Maruyama, Kunio Atsumi, Eiki Shitara, Mizuyo Kurazono, Yuko Kano |
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| Rok vydání: | 2007 |
| Předmět: |
Staphylococcus aureus
Carbapenem Stereochemistry Clinical Biochemistry Molecular Conformation Pharmaceutical Science Pyridinium Compounds Microbial Sensitivity Tests medicine.disease_cause Biochemistry Microbiology Haemophilus influenzae Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Streptococcus pneumoniae medicine Molecular Biology biology Organic Chemistry Stereoisomerism biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Anti-Bacterial Agents Carbapenems chemistry Molecular Medicine Pyridinium Antibacterial activity Bacteria medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry. 15:392-402 |
| ISSN: | 0968-0896 |
| Popis: | A new series of 1β-methyl carbapenems, possessing a 7-substituted imidazo[5,1- b ]thiazol-2-yl group directly attached to the C-2 position of the carbapenem nucleus, was synthesized and evaluated for antibacterial activity. These compounds showed potent activities against Gram-positive bacteria, in particular methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-resistant Streptococcus pneumoniae (PRSP). They also exhibited potent activity against β-lactamase-negative ampicillin-resistant Haemophilus influenzae (BLNAR). |
| Databáze: | OpenAIRE |
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