Microcalcification-associated breast cancer: presentation, successful first excision, long-term recurrence and survival rate
| Autor: | Carolin Steinmetz, Annette Ramaswamy, Ronny Westerman, Ute-Susann Albert, Marga B. Rominger |
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| Přispěvatelé: | University of Zurich, Rominger, Marga B |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
medicine.medical_specialty business.industry 10042 Clinic for Diagnostic and Interventional Radiology 610 Medicine & health medicine.disease Term (time) 2746 Surgery Text mining Breast cancer Internal medicine Medicine Surgery Original Article 2730 Oncology Microcalcification Presentation (obstetrics) medicine.symptom skin and connective tissue diseases business Survival rate |
| DOI: | 10.5167/uzh-125579 |
| Popis: | Introduction: In this study we evaluated mammographic, histological and immunohistochemical findings for microcalcification-associated breast cancer with regards to breast-conserving therapy, recurrence and survival rate. Patients and Methods: We retrospectively analyzed 99 consecutive, non-palpable and microcalcification-associated breast cancers (94 women) that were treated surgically between January 2002 and December 2003 at a national academic breast cancer center. Calcifications were classified according to the Breast Imaging Reporting and Data System (BI-RADS). Descriptors, surgical outcome and histological findings were assessed. Recurrences and survival rates were evaluated based on medical records, standardized patient questionnaires and/or contacting the physician. Results: 42 of the 99 lesions (42.4%) were invasive carcinomas, 57 (57.6%) were pure ductal carcinoma in situ (DCIS). 6 out of 99 (6.1%) lesions were triple negative, and 29 (29.3%) were HER2/neu positive. Successful first excision rate was 76/99 lesions (76.8%). Breast conservation was achieved in 73.7% (73/99). 10 women showed local recurrences without negatively impacting survival. The recurrences included round/punctate, amorphous, fine pleomorphic, and fine linear or fine-linear branching descriptors. The breast cancer-specific long-term survival rate was 91/94 (96.8%) for a mean follow-up of 81.4 months. The 3 patients who died due to breast carcinoma showed fine pleomorphic calcifications, and had nodal-positive invasive carcinoma at diagnosis. Conclusion: Microcalcification-associated breast cancers are frequently treated with breast-conserving therapy. Continuous clinical and mammographic follow-up is recommended for all descriptors. |
| Databáze: | OpenAIRE |
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