Decreased functional connectivity in the fronto-parietal network in children with mood disorders compared to children with dyslexia during rest: An fMRI study
| Autor: | Vaibhav A. Diwadkar, Robert A. Kowatch, David Axelson, Lisa Bonar, Mackenzie Woodburn, Akila Rajagopal, Claudiu Schirda, Mary Kay Gill, Mary A. Fristad, Jeffrey L. Sunshine, Boris Birmaher, Tzipi Horowitz-Kraus, Susan B. Perlman, Sarah M. Horwitz, L. Eugene Arnold, Scott K. Holland, Amelia Versace, Eric A. Youngstrom, Genna Bebko, Thomas W. Frazier, Mary L. Phillips, H. Gerry Taylor, Michele A. Bertocci, Jorge R. C. Almeida, Michael J. Travis, Robert L. Findling |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Psychological intervention Audiology Neuropsychological Tests lcsh:RC346-429 Dyslexia Executive Function 0302 clinical medicine Parietal Lobe Phonological awareness Child Brain Mapping 05 social sciences Cognition Regular Article Magnetic Resonance Imaging Frontal Lobe Behavioral disorders Neurology lcsh:R858-859.7 Female Psychology medicine.medical_specialty Adolescent Cognitive Neuroscience lcsh:Computer applications to medicine. Medical informatics Executive function networks behavioral disciplines and activities 050105 experimental psychology 03 medical and health sciences mental disorders medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging lcsh:Neurology. Diseases of the nervous system Resting state fMRI Mood Disorders Functional Neuroimaging medicine.disease Mood Mood disorders Reading Resting state functional connectivity Neurology (clinical) Nerve Net Neurocognitive 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 18, Iss, Pp 582-590 (2018) |
| ISSN: | 2213-1582 |
| Popis: | Background The DSM-5 separates the diagnostic criteria for mood and behavioral disorders. Both types of disorders share neurocognitive deficits of executive function and reading difficulties in childhood. Children with dyslexia also have executive function deficits, revealing a role of executive function circuitry in reading. The aim of the current study is to determine whether there is a significant relationship of functional connectivity within the fronto-parietal and cingulo-opercular cognitive control networks to reading measures for children with mood disorders, behavioral disorders, dyslexia, and healthy controls (HC). Method Behavioral reading measures of phonological awareness, decoding, and orthography were collected. Resting state fMRI data were collected, preprocessed, and then analyzed for functional connectivity. Differences in the reading measures were tested for significance among the groups. Global efficiency (GE) measures were also tested for correlation with reading measures in 40 children with various disorders and 17 HCs. Results Significant differences were found between the four groups on all reading measures. Relative to HCs and children with mood disorders or behavior disorders, children with dyslexia as a primary diagnosis scored significantly lower on all three reading measures. Children with mood disorders scored significantly lower than controls on a test of phonological awareness. Phonological awareness deficits correlated with reduced resting state functional connectivity MRI (rsfcMRI) in the cingulo-opercular network for children with dyslexia. A significant difference was also found in fronto-parietal global efficiency in children with mood disorders relative to the other three groups. We also found a significant difference in cingulo-opercular global efficiency in children with mood disorders relative to the Dyslexia and Control groups. However, none of these differences correlate significantly with reading measures. Conclusions/significance Reading difficulties involve abnormalities in different cognitive control networks in children with dyslexia compared to children with mood disorders. Findings of the current study suggest increased functional connectivity of one cognitive control network may compensate for reduced functional connectivity in the other network in children with mood disorders. These findings provide guidance to clinical professionals for design of interventions tailored for children suffering from reading difficulties originating from different pathologies. Highlights • Significant differences were found between children with mood vs those with behavioral disorders and children with dyslexia • Phonological awareness correlated with reduced connectivity in both the fronto-parietal and the cingulo-opercular networks in dyslexia • Differences in fronto-parietal global efficiency in children with mood disorders vs the other three groups |
| Databáze: | OpenAIRE |
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