Discovery of nitropyridyl-based dichloropropene ethers as insecticides
| Autor: | Xiaoming Ou, Long Chuyun, Minhua Liu, Aiping Liu, Yeguo Ren, Yu Hong, Guorong Shi, Mingzhi Huang, Xinping Liu, Wanqi Yu, Lu Huang |
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| Rok vydání: | 2019 |
| Předmět: |
Insecticides
Molecular Structure Pyridines 010405 organic chemistry Chemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Ether Moths 01 natural sciences Biochemistry 0104 chemical sciences Structure-Activity Relationship 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Drug Discovery Propyl ether Animals Molecular Medicine Organic chemistry Molecular Biology Ethers |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 29:1430-1433 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2018.12.055 |
| Popis: | A series of nitropyridyl-based dichloropropene ethers were prepared and evaluated for their insecticidal activities against main lepidopteran pests such as M. separate, P. xylostella and P. litura. The compounds showed a broad-spectrum of remarkable insecticidal activities. Especially 4a (2,6-dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-nitro-2-pyridyloxy]propyl ether) and 11a (2-(4-(3-(2,6-dichloro-4-((3,3-dichloroallyl)oxy)phenoxy)propoxy)phenoxy)-5-nitropyridine) displayed potent activities comparable to that of Pyridalyl, the only commercialized dichloropropene ether insecticide thus far. The structure-activity relationship was also discussed. |
| Databáze: | OpenAIRE |
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