The role of Orexin-A levels in epileptic seizure
| Autor: | Omer Faruk Bayraktutan, Gönül Gürol Ciftci, Dilcan Kotan, Mustafa Ceylan, Murat Yücel, Halil İbrahim Çıkrıklar, Ihsan Hakki Ciftci |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Pediatrics medicine.medical_specialty Diagnosis Differential 03 medical and health sciences Epilepsy Orexin-A 0302 clinical medicine Seizures medicine Humans Psychogenic disease In patient Orexins business.industry General Neuroscience Venous blood Middle Aged medicine.disease 030104 developmental biology Biomarker (medicine) Female Epileptic seizure medicine.symptom Differential diagnosis business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience Letters. 734:135097 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2020.135097 |
| Popis: | The aim of this study is to determine the usefulness of Orexin-A levels in differentiating between epileptic seizures and psychogenic non-epileptic seizures in patients presenting to the emergency service with epileptic seizure-type symptoms.A total of 80 individuals were included in this study, including 59 who presented to the emergency service within the first four hours of having been diagnosed with generalized tonic-clonic seizures (39 with epileptic seizures (ES) and 20 with pseudoseizures (PNES) and 21 controls. Orexin-A levels were measured in venous blood samples.The mean Orexin-A levels were 5.16 ng/mL in the control group, 7.17 ng/mL in the PNES group, and 11.08 ng/mL in the ES group (Table 1). The mean Orexin-A level of the ES group was significantly different from both the control group and the PNES group (Table 1, p 0.001); the difference between the control group and the PNES group was not significant (p 0.05).Results of this study suggest that blood Orexin-A may be an effective biomarker in the differential diagnosis of epileptic seizures/psychogenic non-epileptic seizures in patients presenting to the emergency service with an epileptic seizure-type clinical picture. |
| Databáze: | OpenAIRE |
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