PET imaging in a longitudinal non-Hodgkin's lymphoma study: association with tumor volume
| Autor: | Xingchen Wu, Maija Rossi, Hannu Eskola, Hannu Pertovaara, Ritva Järvenpää, Prasun Dastidar, Pasi Korkola, Seppo Soimakallio, Pirkko-Liisa Kellokumpu-Lehtinen |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Standardized uptake value Physical examination Fluorodeoxyglucose F18 medicine Humans Radiology Nuclear Medicine and imaging Longitudinal Studies Aged Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Magnetic resonance imaging General Medicine Pet imaging Middle Aged Prognosis medicine.disease Hodgkin Disease Magnetic Resonance Imaging Tumor Burden Lymphoma Non-Hodgkin's lymphoma Positron emission tomography Positron-Emission Tomography Female Radiology Tomography Tomography X-Ray Computed Nuclear medicine business |
| Zdroj: | Acta Radiologica. 52:995-1002 |
| ISSN: | 1600-0455 0284-1851 |
| DOI: | 10.1258/ar.2011.110099 |
| Popis: | Background Computed tomography (CT) is generally used in the evaluation of the treatment response of non-Hodgkin's lymphoma (NHL) patients. Instead of morphological images, positron emission tomography (PET) shows metabolic information that is connected to tumor activity, cell proliferation rate, and, thus, prognosis. Purpose To determine the prognostic value of PET for tumor volume reduction measured by CT and magnetic resonance imaging (MRI) along with clinical characteristics in NHL patients. Material and Methods We imaged 21 B-cell type NHL patients using whole-body 18F-FDG-PET at the onset and the completion of treatment and at six-month follow-up. The maximum standardized uptake value (SUVmax) was calculated. Morphological tumor volume calculations were assessed using both MRI and CT. Additionally, patients underwent thorough clinical examination including several laboratory tests. Results A high SUVmax was able to predict significant tumor volume reduction at the beginning of treatment, but the relation to pure tumor volume was poor. Conclusion The SUVmax values derived from FDG-PET seemed to correlate with volume changes but not with their absolute values or laboratory tests. Unlike MRI and CT, FDG-PET showed the disappearance of active tumors after treatment. |
| Databáze: | OpenAIRE |
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