Reduced hepatocyte fatty acid oxidation in outbred rats prescreened for susceptibility to diet-induced obesity
| Autor: | M I Friedman, H Ji |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Palmitates Medicine (miscellaneous) Rats Sprague-Dawley Fat oxidation Plasma triglyceride Internal medicine medicine Animals Genetic Predisposition to Disease Obesity Beta oxidation Cells Cultured Triglycerides Nutrition and Dietetics Chemistry Carbohydrate medicine.disease In vitro Diet Rats Endocrinology medicine.anatomical_structure Hepatocyte Obesity prone Hepatocytes Oxidation-Reduction |
| Zdroj: | International Journal of Obesity. 32:1331-1334 |
| ISSN: | 1476-5497 0307-0565 |
| DOI: | 10.1038/ijo.2008.71 |
| Popis: | Rats vary in their propensity to become obese when eating a high-fat diet, but the factors that make some rats susceptible and others resistant to diet-induced obesity are unclear. Recent studies show that rats predisposed to diet-induced obesity have a preexisting deficit in fat oxidation and suggest that this impairment is due in part to reduced fatty acid oxidation in liver. To determine directly whether rats susceptible to diet-induced obesity are less able to oxidize fatty acids in liver, we measured palmitate oxidation in hepatocytes isolated from outbred Sprague-Dawley rats that were identified while still eating a low-fat diet as obesity-prone or obesity-resistant by using a new screening procedure based on the change in plasma triglyceride concentration produced by an intragastric load of a fat and carbohydrate mixture. The results showed that hepatocytes from rats thus identified as obesity-prone oxidized 44% less palmitate in vitro than did those from obesity-resistant rats. This difference in hepatocyte fatty acid oxidation is consistent with and may explain at least in part the reduced capacity of obesity-prone rats to oxidize fat. |
| Databáze: | OpenAIRE |
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