Development of an IL-6 point-of-care assay: utility for real-time monitoring and management of cytokine release syndrome and sepsis
| Autor: | Ling Wang, Saloumeh K Fischer, Emmanuel Capio, Kathi Williams, Mikhail Briman |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Point-of-care testing Clinical Biochemistry 030204 cardiovascular system & hematology Analytical Chemistry Sepsis 03 medical and health sciences 0302 clinical medicine Clinical decision making Limit of Detection Humans Medicine General Pharmacology Toxicology and Pharmaceutics Interleukin 6 Intensive care medicine Point of care biology Interleukin-6 business.industry Critically ill Equipment Design General Medicine medicine.disease Medical Laboratory Technology Cytokine release syndrome Point-of-Care Testing 030220 oncology & carcinogenesis biology.protein Cytokine Release Syndrome business |
| Zdroj: | Bioanalysis. 11:1777-1785 |
| ISSN: | 1757-6199 1757-6180 |
| DOI: | 10.4155/bio-2019-0192 |
| Popis: | Aim: Bedside or point-of-care testing (POCT) provides immediate results, allowing for rapid clinical decision making and management of critically ill patients. IL-6 is a central mediator in cytokine release syndrome and sepsis, two potentially life-threatening events. A real-time point-of-care measurement of IL-6 readily available in hospitals and/or to clinicians could provide a valuable tool for decision making. Materials & methods: An IL-6 assay is developed on a POCT device (Proxim, CA, USA), with comparison data measured by ELISA, Ella, and the Roche Cobas. Results: Samples evaluated on a Proxim POCT device showed good correlation with data from multiple platforms. Conclusions: An IL-6 point-of-care assay was developed as potential tool for rapid clinical decision making and management of patients with sepsis and/or cytokine release syndrome. |
| Databáze: | OpenAIRE |
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