Induction of memory-like dendritic cell responses in vivo
| Autor: | Floyd L. Wormley, Hong Cai, Chrissy M. Leopold Wager, Althea Campuzano, Yufeng Wang, Natalia Castro-Lopez, Karen L. Wozniak, Camaron R. Hole |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment General Physics and Astronomy 02 engineering and technology Histones Interferon lcsh:Science Lung Innate immunity Mice Inbred BALB C Multidisciplinary Vaccination food and beverages Cryptococcosis 021001 nanoscience & nanotechnology 3. Good health Phenotype Cytokine Mucosal immunology Female 0210 nano-technology medicine.drug Science chemical and pharmacologic phenomena Biology Article General Biochemistry Genetics and Molecular Biology Interferon-gamma 03 medical and health sciences Immune system Immunity medicine Animals RNA Messenger Inflammation Innate immune system Dendritic Cells Antimicrobial responses General Chemistry Dendritic cell biochemical phenomena metabolism and nutrition Immunity Innate Innate immune cells Cryptococcus 030104 developmental biology Infectious disease (medical specialty) Immunology bacteria lcsh:Q Immunologic Memory Protein Processing Post-Translational |
| Zdroj: | Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Dendritic cells (DCs), a vital component of the innate immune system, are considered to lack antigen specificity and be devoid of immunological memory. Strategies that can induce memory-like responses from innate cells can be utilized to elicit protective immunity in immune deficient persons. Here we utilize an experimental immunization strategy to modulate DC inflammatory and memory-like responses against an opportunistic fungal pathogen that causes significant disease in immunocompromised individuals. Our results show that DCs isolated from protectively immunized mice exhibit enhanced transcriptional activation of interferon and immune signaling pathways. We also show long-term memory-like cytokine responses upon subsequent challenge with the fungal pathogen that are abrogated with inhibitors of specific histone modifications. Altogether, our study demonstrates that immunization strategies can be designed to elicit memory-like DC responses against infectious disease. Wormley and colleagues present data showing that vaccine strategies can be devised to prime dendritic cells to respond in a memory-like fashion upon subsequent exposure to a pathogen. |
| Databáze: | OpenAIRE |
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