The Relationship Between Copper, Iron, and Selenium Levels and Alzheimer Disease
| Autor: | Guilherme Barroso Langoni de Freitas, Felipe Nathanael Coelho Vaz, Juliana Sartori Bonini, Jéssica Wouk, Roberta Fabbri, João Rocha, Maria Vaitsa Loch Haskel, Erik Montagna, Bárbara Luisa Fermino |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Gerontology Male medicine.medical_specialty Clinical Dementia Rating Endocrinology Diabetes and Metabolism Iron Clinical Biochemistry chemistry.chemical_element Biochemistry Gastroenterology Mass Spectrometry Inorganic Chemistry 03 medical and health sciences Selenium 0302 clinical medicine Alzheimer Disease Internal medicine Statistical analyses medicine Elderly people Humans Cognitive impairment Aged Biochemistry (medical) Significant difference General Medicine medicine.disease Copper 030104 developmental biology chemistry Female Alzheimer's disease 030217 neurology & neurosurgery |
| Zdroj: | Biological trace element research. 181(2) |
| ISSN: | 1559-0720 |
| Popis: | This study aimed to evaluate the concentrations of copper, iron, and selenium in elderly people with Alzheimer disease (AD), comparing the same parameters in a paired group of healthy people, in order to verify if the amount of these metals may influence the cognitive impairment progression. Patients' cognitive impairment was evaluated by Clinical Dementia Rating (CDR). The elementary quantification of erythrocytes was performed by inductively coupled plasma mass spectrometry technique. The statistical analyses were carried out by SPSS software 20.0 version, employing Shapiro-Wilk, Wilcoxon, Kruskall-Wallis, and Spearman correlation tests, considering significant results of p |
| Databáze: | OpenAIRE |
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