Characterization of thylakoid lipid membranes from cyanobacteria and higher plants by molecular dynamics simulations
| Autor: | Alex H. de Vries, Tsjerk A. Wassenaar, Siewert J. Marrink, Djurre H. de Jong, Floris J. van Eerden |
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| Přispěvatelé: | Molecular Dynamics |
| Rok vydání: | 2015 |
| Předmět: |
Photosynthetic reaction centre
PARTICLE MESH EWALD LATERAL DIFFUSION BILAYERS Photosystem II Plastoquinone Lipid Bilayers Static Electricity Molecular Conformation Biophysics DEEPOXIDATION Glycolipid Molecular dynamics Molecular Dynamics Simulation Biology Cyanobacteria Photosynthesis Thylakoids Biochemistry Thylakoid membrane Diffusion chemistry.chemical_compound FUSION PHOTOSYSTEM-II Spinacia oleracea HEXAGONAL PHASE-TRANSITIONS Martini forcefield FATTY-ACID DESATURATION food and beverages Galactolipids Intracellular Membranes Cell Biology Lipids Coarsegrained Kinetics Membrane chemistry Thylakoid Quantasome lipids (amino acids peptides and proteins) MARTINI FORCE-FIELD BEHAVIOR |
| Zdroj: | Biochimica et Biophysica Acta-Biomembranes, 1848(6), 1319-1330. Elsevier |
| ISSN: | 0005-2736 |
| DOI: | 10.1016/j.bbamem.2015.02.025 |
| Popis: | The thylakoid membrane is mainly composed of non-common lipids, so called galactolipids. Despite the importance of these lipids for the function of the photosynthetic reaction centers, the molecular organization of these membranes is largely unexplored. Here we use multiscale molecular dynamics simulations to characterize the thylakoid membrane of both cyanobacteria and higher plants. We consider mixtures of up to five different galactolipids plus phosphatidylglycerol to represent these complex membranes. We find that the different lipids generally mix well, although nanoscale heterogeneities are observed especially in case of the plant membrane. The fluidity of the cyanobacterial membrane is markedly reduced compared to the plant membrane, even considering elevated temperatures at which thermophilic cyanobacteria are found. We also find that the plant membrane more readily undergoes a phase transformation to an inverted hexagonal phase. We furthermore characterized the conformation and dynamics of the cofactors plastoquinone and plastoquinol, revealing of the fast flip-flop rates for the non-reduced form. Together, our results provide a molecular view on the dynamical organization of the thylakoid membrane. (C) 2015 Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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