Modulation of decompression sickness risk in pigs with caffeine during H(2) biochemical decompression
| Autor: | Susan R. Kayar, William B. Whitman, Andreas Fahlman, Winston Lin |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Decompression
Male Methanobacteriaceae Physiology Swine Injections Decompression sickness chemistry.chemical_compound Animal model Oxygen Consumption Physiology (medical) Caffeine medicine Animals business.industry medicine.disease Decompression Sickness Intestines Atmospheric Pressure chemistry Anesthesia Breathing Central Nervous System Stimulants business Hydrogen |
| Zdroj: | Journal of applied physiology (Bethesda, Md. : 1985). 93(5) |
| ISSN: | 8750-7587 |
| Popis: | In H2biochemical decompression, H2-metabolizing intestinal microbes remove gas stored in tissues of animals breathing hyperbaric H2, thereby reducing decompression sickness (DCS) risk. We hypothesized that increasing intestinal perfusion in pigs would increase the activity of intestinal Methanobrevibacter smithii, lowering DCS incidence further. Pigs ( Sus scrofa,17–23 kg, n = 20) that ingested caffeine (5 mg/kg) increased O2consumption rate in 1 atm air by ∼20% for at least 3 h. Pigs were given caffeine alone or caffeine plus injections of M. smithii. Animals were compressed to 24 atm (20.5–23.1 atm H2, 0.3–0.5 atm O2) for 3 h, then decompressed and observed for signs of DCS. In previous studies, DCS incidence in animals without caffeine treatment was significantly ( P < 0.05) lower with M. smithii injections (7/16) than in controls (9/10). However, contrary to our hypothesis, DCS incidence was marginally higher ( P = 0.057) in animals that received caffeine and M. smithii (9/10) than in animals that received caffeine but no M. smithii (4/10). More information on gas kinetics is needed before extending H2biochemical decompression to humans. |
| Databáze: | OpenAIRE |
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