Effect of Chlorogenic Acids on Cognitive Function in Mild Cognitive Impairment: A Randomized Controlled Crossover Trial
| Autor: | Katsuyoshi Saitou, Chika Suzukamo, Ryuji Ochiai, Noriko Osaki, Takashi Asada |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty chlorogenic acid Trail Making Test coffee Neuropsychological Tests Placebo crossover studies 03 medical and health sciences Executive Function 0302 clinical medicine mild cognitive impairment Cognition Japan Internal medicine medicine Humans In patient Attention Cognitive Dysfunction Cognitive impairment Nootropic Agents Aged Aged 80 and over trail making test Cross-Over Studies business.industry General Neuroscience General Medicine Middle Aged Crossover study Psychiatry and Mental health Clinical Psychology polyphenol 030104 developmental biology Treatment Outcome Female Disease assessment Geriatrics and Gerontology Completion time business human activities 030217 neurology & neurosurgery Research Article |
| Zdroj: | Journal of Alzheimer's Disease |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Background: Mild cognitive impairment (MCI) is a global-scale issue, due in large part to the rapidly growing elderly population. The main polyphenol contained in coffee beans, chlorogenic acid (CGA), improves attention in healthy individuals. The utility of CGAs for treating MCI, however, has not been evaluated. Objective: To determine the effects of continuous CGA intake on cognitive function, especially attention, in patients diagnosed with MCI. Methods: The study was a randomized controlled crossover trial including 34 patients with MCI. Participants were randomly divided into two groups: Those who first ingested a placebo beverage and those who first ingested an active beverage containing CGAs (553.6 mg/bottle) twice daily for 12 weeks. After a 4-week washout period, the subjects ingested the other beverage (i.e., placebo or active beverage) in the same manner. Endpoint measures included scores on the Japanese version of the Mini-Mental State Examination (MMSE), the Japanese version of the Alzheimer’s Disease Assessment Scale-cognitive component (ADAS-cog) testing overall cognitive function, and the Japanese version of the Trail Making Test (TMT-A, TMT-B) testing attention, along with the results of blood tests to evaluate safety. Results: In the TMT-B test, participants had a significantly reduced number of errors while ingesting the CGA beverage as compared with the placebo beverage (p |
| Databáze: | OpenAIRE |
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