Combined cardiac sympathetic excitation and vagal impairment in patients with non-organic erectile dysfunction
| Autor: | Chih J. Chen, Cheryl C.H. Yang, Terry B.J. Kuo, Yi Jhan Tseng |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Vagus Nerve Diseases medicine.medical_specialty Sympathetic nervous system Electrocardiography Young Adult Erectile Dysfunction Heart Rate Physiology (medical) Internal medicine Heart rate medicine Heart rate variability Humans Aged Retrospective Studies Analysis of Variance medicine.diagnostic_test Spectrum Analysis Case-control study Age Factors Middle Aged medicine.disease Sensory Systems Autonomic nervous system Erectile dysfunction medicine.anatomical_structure Endocrinology Neurology Case-Control Studies Trazodone Cardiology Neurology (clinical) Analysis of variance Psychology Selective Serotonin Reuptake Inhibitors |
| Zdroj: | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 120(2) |
| ISSN: | 1872-8952 |
| Popis: | Objective Patients with non-organic erectile dysfunction (ED) frequently present with syndromes involving systemic sympathovagal dysfunction. The linkage of ED to cardiac autonomic regulation is not well understood. Methods Forty-four men with non-organic ED and 38 healthy age-matched control subjects with ages ranging from 40 years to 69 years were recruited. These two groups were divided into three distinct age categories at 10-year intervals. Patients were divided into three different severity categories, among whom 35 patients received a two-month oral treatment of trazodone. Power spectral analysis of successive R-R intervals (RR) was performed to evaluate the variance (variance of RR-interval values), the high-frequency power (HF), and the ratio of low-frequency power to HF (LF/HF) of their heart rate variability (HRV). Results Patients exhibited a significantly lower variance and HF, but a higher LF/HF compared to the control group across all age categories. The changes in variance and HF were severity dependent. In addition, all the HRV parameters of the patients with a satisfactory response after treatment have significantly improved. Conclusion The results indicate that patients with non-organic ED had significant cardiac sympathetic hyperactivity and severity-dependent cardiac vagal impairment. Significance Non-organic ED may be accompanied by an abnormality in cardiac autonomic regulation. |
| Databáze: | OpenAIRE |
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