Synthesis of novel benzo[h]quinolines: Wound healing, antibacterial, DNA binding and in vitro antioxidant activity
| Autor: | Halehatty R. Prakash Naik, B.M. Khadeer Ahamed, H. Raja Naika, Kuluvar Gouthamchandra, Halehatty S. Bhojya Naik, Riaz Mahmood, Thangali R. Ravikumar Naik |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Staphylococcus aureus Magnetic Resonance Spectroscopy Antioxidant Streptococcus pyogenes DPPH medicine.medical_treatment Microbial Sensitivity Tests Bacillus subtilis Nucleic Acid Denaturation Chemical synthesis Antioxidants Mass Spectrometry chemistry.chemical_compound Drug Discovery medicine Animals Rats Wistar Antibacterial agent Pharmacology Wound Healing biology Organic Chemistry Biological activity DNA General Medicine biology.organism_classification Anti-Bacterial Agents Rats chemistry Biochemistry Quinolines Wound healing |
| Zdroj: | European Journal of Medicinal Chemistry. 44:981-989 |
| ISSN: | 0223-5234 |
| DOI: | 10.1016/j.ejmech.2008.07.006 |
| Popis: | We have characterized a new class of 2-mercapto/2-selenobenzo[h]quinoline-3-carbaldehyde (3/4). Antibacterial potential of these compounds against a wide range of Gram-positive and Gram-negative bacteria was studied. The selenium containing compound 4 showed significant inhibition zone on Staphylococcus aureus (22.76 ± 0.14), Bacillus subtilis (20.63 ± 0.24), and Streptococcus pyogenes (19.54 ± 0.20) over sulfur containing compound 3. To validate the ethnotherapeutic claims of the synthetic compounds in skin diseases, wound healing activity was studied, besides antioxidant activity to understand the mechanism of wound healing. The interaction behavior of these compounds with DNA was investigated by absorption spectra (obtained Kb constant for 3 is 2.7 × 105 and for 4 is 3.8 × 106), viscosity, and thermal denaturation studies. Finally, the results show that the DNA intercalated 3/4 compounds are strong antioxidants; they show significan wound healing activity and protect oxidative DNA damage from harmful free radical reactions. |
| Databáze: | OpenAIRE |
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