Ultrashort Time to Echo Magnetic Resonance Evaluation of Calcium Pyrophosphate Crystal Deposition in Human Menisci
| Autor: | Sheronda Statum, Robert M. Healey, Palanan Siriwanarangsun, Tim Finkenstaedt, Won C. Bae, Christine B. Chung, Reni Biswas, Nirusha A. Abeydeera |
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| Přispěvatelé: | University of Zurich, Chung, Christine B |
| Rok vydání: | 2019 |
| Předmět: |
Male
X-ray microtomography Knee Joint Image Processing Meniscus (anatomy) Calcium Pyrophosphate 030218 nuclear medicine & medical imaging chemistry.chemical_compound Computer-Assisted 0302 clinical medicine Nuclear magnetic resonance meniscus Image Processing Computer-Assisted medicine.diagnostic_test 10042 Clinic for Diagnostic and Interventional Radiology Quantitative mr Calcium pyrophosphate General Medicine Middle Aged musculoskeletal system Magnetic Resonance Imaging Biomechanical Phenomena Nuclear Medicine & Medical Imaging medicine.anatomical_structure calcium pyrophosphate deposition disease Biomedical Imaging Female ultrashort echo time musculoskeletal diseases Materials science Clinical Sciences 610 Medicine & health Bioengineering Article 03 medical and health sciences Cadaver medicine 2741 Radiology Nuclear Medicine and Imaging Humans Meniscus Radiology Nuclear Medicine and imaging Extramural Magnetic resonance imaging X-Ray Microtomography body regions chemistry Crystal deposition UTE Cadaveric spasm indentation testing 030217 neurology & neurosurgery |
| Zdroj: | Investigative radiology, vol 54, iss 6 Invest Radiol |
| ISSN: | 0020-9996 |
| DOI: | 10.1097/rli.0000000000000547 |
| Popis: | ObjectivesIn human menisci, we aimed to investigate whether calcium pyrophosphate crystal deposition (CPPD) affects biomechanical and quantitative MR properties, and their zonal distribution.Materials and methodsFrom 9 cadaveric knees, sectioned triangular meniscus pieces were harvested. Samples were classified into "normal" or "CPPD" groups based upon visual inspection. Micro computed tomography scan verified CPPD. Using magnetic resonance imaging, ultrashort echo time (UTE) T2* and spin echo (SE) T2, quantitative values in 3 zones (red, red-white, and white) were determined. Using biomechanical test, indentation forces in the same zones were determined. Effects of CPPD and meniscal zone on indentation force and quantitative MR values were compared.ResultsOn UTE MRI scans, CPPD-affected menisci exhibited punctate dark regions, found mostly (92%) in avascular white and red-white zones. Indentation forces were significantly higher for CPPD samples in the red-white (all P < 0.02) and white (all P < 0.004) zones but not in the vascular red zone (all P > 0.2). Similarly, UTE T2* red zone values were similar between both groups (~6.6 milliseconds, P = 0.8), whereas in the red-white and white zones, CPPD samples had significantly lower values (~5.1 milliseconds, P = 0.005 to 0.007). In contrast, SE T2 values showed no difference with CPPD (P = 0.12 to 0.16). UTE T2*, but not SE T2, correlated significantly with indentation force (R = -0.29, P = 0.009).ConclusionsDark CPP deposits were detectable on UTE images featuring high signal intensity from surrounding meniscal tissue. Preliminary results indicate that CPP deposits were almost exclusively found in the avascular zones. Compared with normal, CPPD menisci featured higher indentation stiffness and lower UTE T2* values in the affected zones. |
| Databáze: | OpenAIRE |
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