Differential activity of interleukin 1α and interleukin 1β in the stimulation of the immune responsein vivo
| Autor: | Pietro Ghezzi, Luigi Villa, Gianfranco Volpini, Giuseppe Scapigliat, Manuela Mengozzi, Franca Cioli, Giacomo Matteucci, Marzia Carnasciali, S Censini, Aldo Tagliabue, Enza Olmastroni, P. Ghiara, Luciano Nencioni, Diana Boraschi, M Bartalini, Paola Bossù |
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| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_treatment
Immunology Alpha (ethology) In Vitro Techniques Biology Recombinant Interleukin Lymphocyte Activation Dinoprostone Mice Immune system Antigen In vivo medicine Animals Humans Immunology and Allergy Beta (finance) Inflammation Mice Inbred C3H Pyrogens Interleukin Recombinant Proteins Cytokine Antibody Formation Rabbits Interleukin-1 |
| Zdroj: | European Journal of Immunology. 20:317-321 |
| ISSN: | 1521-4141 0014-2980 |
| Popis: | The biological activities of human recombinant interleukin (IL) 1 alpha and IL 1 beta were compared in different biological systems. The two IL 1 forms were equally active in vitro in inducing proliferation of murine thymocytes and of the murine T helper clone D10.G4.1, and in triggering release of prostaglandin E2 from human skin fibroblasts. In vivo, IL 1 alpha and IL 1 beta were similarly pyrogenic both in rabbits and mice, and could equally increase the circulating levels of the acute phase protein serum amyloid A in mice. However, only IL 1 beta showed immunostimulatory activity in vivo, as it could enhance the number of specific antibody-producing cells in the spleen of mice immunized with either a T-dependent or a T-independent antigen. Although devoid of immunostimulatory activity, IL 1 alpha could efficiently compete immunostimulation induced by IL 1 beta, suggesting an effective interaction with the IL 1 receptor. Thus, IL 1 beta appears to have an important role in the positive regulation of immune responses, while IL 1 alpha may act as down-regulator of the IL 1 beta effect. |
| Databáze: | OpenAIRE |
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