The acute systemic toxicity of thallium in rats produces oxidative stress: attenuation by metallothionein and Prussian blue
| Autor: | Sergio Montes, Marisela Méndez-Armenta, Laura Anaya-Ramos, Sara García-Jiménez, Verónica Baron-Flores, Antonio Monroy-Noyola, Camilo Ríos, Yoshajandith Aguirre-Vidal, Araceli Diaz-Ruiz |
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| Rok vydání: | 2021 |
| Předmět: |
Male
chemistry.chemical_element Spleen Pharmacology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Biomaterials chemistry.chemical_compound medicine Animals Metallothionein Rats Wistar Thallium Diminution Kidney Metals and Alloys Glutathione Rats Oxidative Stress medicine.anatomical_structure chemistry Toxicity General Agricultural and Biological Sciences Oxidative stress Ferrocyanides |
| Zdroj: | BioMetals. 34:1295-1311 |
| ISSN: | 1572-8773 0966-0844 |
| DOI: | 10.1007/s10534-021-00343-8 |
| Popis: | Thallium (TI) is one of the most toxic heavy metals. Human exposure to Tl occurs through contaminated drinking water and from there to food, a threat to health. Recently, environmental contamination by Tl has been reported in several countries, urging the need for studies to determine the impact of endogenous and exogenous mechanisms preventing thallium toxicity. The cytoprotective effect of metallothionein (MT), a protein with high capacity to chelate metals, at two doses (100 and 600 µg/rat), was tested. Prussian blue (PB) (50 mg/kg) was administered alone or in combination with MT. A dose of Tl (16mg/kg) was injected i.p. to Wistar rats. Antidotes were administered twice daily, starting 24h after Tl injection, for 4 days. Tl concentrations diminished in most organs (p |
| Databáze: | OpenAIRE |
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