Intraepidermal IgA pustulosis

Autor: Agop Kotoğyan, Cuyan Demirkesen, M. Cem Mat, Gökhan Gokler
Rok vydání: 1997
Předmět:
Zdroj: Journal of the European Academy of Dermatology and Venereology. 9:161-165
ISSN: 0926-9959
DOI: 10.1016/s0926-9959(97)00040-8
Popis: Background Intraepidermal IgA pustulosis is a rare vesiculopustular condition characterized by intercellular IgA deposits, neutrophilic infiltration and mild acantholysis. This condition is usually reported in middle-aged or elderly people. We present the clinical, histological and immunofluorescence data of a child with this condition. Observation Our case is an 11-year-old girl who presented a pruritic vesiculopustular eruption involving the trunk, upper extremities, face and oral mucosa. Histopathologic examination revealed an intraepidermal pustule formation composed of neutrophils and some eosinophils and acantholytic cells in the spinal layer. Direct immunofluorescent test showed the deposition of IgA in the intercellular spaces throughout the whole of the epidermis. No circulating IgA anti-intercellular antibodies were detected by indirect immunofluorescence. She was treated with prednisolone 30 mg/daily. After discontinuation of corticosteroid treatment, we did not observe any skin lesions during a follow-up period of 2 years. Conclusion We consider this eruption intraepidermal IgA pustulosis (histologically intraepidermal neutrophilic type) based on clinical and histopathological findings. Intraepidermal IgA pustulosis should be considered in the differential diagnosis of vesiculopustular eruption in childhood.
Databáze: OpenAIRE
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