Effect of READ1 on latent profiles of reading disorder and comorbid attention and language impairment subtypes
| Autor: | Jeffrey R. Gruen, Mellissa M C DeMille, Jan C. Frijters, Joan Bosson-Heenan, Miao Li, Maureen W. Lovett, Jeffrey G. Malins, Dongnhu T. Truong |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Adolescent Population Phonological deficit Comorbidity Article Dyslexia 03 medical and health sciences 0302 clinical medicine DCDC2 Developmental and Educational Psychology medicine Attention deficit hyperactivity disorder Humans 0501 psychology and cognitive sciences Attention Language Development Disorders education Child Alleles Genetic association Language education.field_of_study Learning Disabilities 05 social sciences medicine.disease Genetic architecture Neuropsychology and Physiological Psychology Reading Attention Deficit Disorder with Hyperactivity Pediatrics Perinatology and Child Health Female medicine.symptom Psychology Neurocognitive Microtubule-Associated Proteins 030217 neurology & neurosurgery 050104 developmental & child psychology Clinical psychology |
| Zdroj: | Child Neuropsychol |
| ISSN: | 1744-4136 |
| Popis: | Recent studies of co-occurring reading disorder (RD) and attention deficit/hyperactivity disorder (ADHD), and co-occurring RD and language impairment (LI), support a core disability plus co-occurrence model focused on language and attention. Genetic factors have been associated with poor reading performance. However, little is known about whether different genetic variants independently contribute to RD co-occurrence subtypes. We aimed to identify subgroups of struggling readers using a latent profile analysis (LPA) in a sample of 1,432 Hispanic American and African American youth. RD classes were then tested for association with variants of READ1, a regulatory element within the candidate RD risk gene, DCDC2. Six groups were identified in the LPA using RD designation as a known-class variable. The three RD classes identified groups of subjects with neurocognitive profiles representing RD+ADHD, specific phonological deficit RD, and RD+LI. Genetic associations across RD subtypes were investigated against functional groupings of READ1. The RU1-1 group of READ1 alleles was associated with RD cases that were marked by deficits in both processing speed and attention (RD + ADHD). The DCDC2 microdeletion that encompasses READ1 was associated with RD cases showing a phonological deficit RD profile. These findings provide evidence for differential genetic contribution to RD subtypes, and that previously implicated genetic variants for RD may share an underlying genetic architecture across population groups for reading disorder. |
| Databáze: | OpenAIRE |
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