Diastereoselective Synthesis of Fused Lactone-Pyrrolidinones; Application to a Formal Synthesis of (−)-Salinosporamide A
| Autor: | Michal S. Hallside, Leo Marx, Simon J. Sprague, Amber L. Thompson, Angus W. J. Logan, Jonathan W. Burton, Vincenzo Garzya, Robert W. Foster |
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| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Molecular Structure Stereochemistry Organic Chemistry Stereoisomerism Biochemistry Radical cyclization Pyrrolidinones Lactones Formal synthesis chemistry.chemical_compound chemistry Cyclization Pyrroles Physical and Theoretical Chemistry Oxidation-Reduction Salinosporamide A Lactone |
| Zdroj: | Organic Letters. 16:4078-4081 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol501662t |
| Popis: | A mild, diastereoselective synthesis of fused lactone-pyrrolidinones using an oxidative radical cyclization is reported. The methodology is demonstrated in a formal synthesis of (-)-salinosporamide A. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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