The −1082A/G polymorphism in the Interleukin-10 gene and the risk of rheumatoid arthritis: A meta-analysis
| Autor: | Jianxi Lu, Ruiping Cheng, Jing Jin, Kejian Xie, Cong Chen, Jie Zhang, Min Li, Chaowei Wen, Yonggang Zhang |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Immunology Biochemistry Gastroenterology Arthritis Rheumatoid Polymorphism (computer science) Internal medicine Humans Immunology and Allergy Medicine Genetic Predisposition to Disease Allele Molecular Biology Gene Polymorphism Genetic business.industry Hematology Odds ratio medicine.disease Confidence interval Interleukin-10 Interleukin 10 Rheumatoid arthritis Meta-analysis business |
| Zdroj: | Cytokine. 56:351-355 |
| ISSN: | 1043-4666 |
| DOI: | 10.1016/j.cyto.2011.05.022 |
| Popis: | A large number of studies have shown that the -1082A/G polymorphism (rs1800896) in the Interleukin-10 gene (IL-10) is implicated in the susceptibility to rheumatoid arthritis (RA). However, the results are inconsistent and inconclusive. The aim of this study is to analyze the association between the -1082A/G polymorphism in the IL-10 gene and the RA risk by meta-analysis. A total of 1480 cases and 1413 controls in 10 case-control studies were included in this meta-analysis. The results indicated that the G allele carriers (GG+GA) had a 25% decreased risk of RA, when compared with the homozygote AA (odds ratio (OR)=0.75, 95% confidence interval (CI): 0.59-0.93). In the analysis in Europeans, significant decreased risks were associated with the G allele carriers (OR=0.73 and 95% CI: 0.57-0.93 for GG+GA vs. AA). The results from this meta-analysis provide evidence for the association between the IL-10 -1082A/G polymorphism and the risk of RA. To further evaluate gene×gene and gene×environment interactions between the polymorphisms in the IL-10 gene and RA risk, more studies with large groups of patients are required. |
| Databáze: | OpenAIRE |
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