Characteristics of subjects with very low serum low-density lipoprotein cholesterol and the risk for intracerebral hemorrhage
| Autor: | Gwanpyo Koh, Dae Ho Lee, So Yeon Yoo, Jung Re Yu, Jae-Geun Lee, Sung Joo Koh, Sang Ah Lee |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Alcohol Drinking Down-Regulation Gastroenterology Risk Assessment Cerebral hemorrhage chemistry.chemical_compound Risk Factors Internal medicine Republic of Korea medicine Humans cardiovascular diseases Aged Dyslipidemias Retrospective Studies Intracerebral hemorrhage business.industry Cholesterol Incidence (epidemiology) Incidence Liver Diseases Low-density lipoprotein Statins Retrospective cohort study Cholesterol LDL Middle Aged medicine.disease nervous system diseases Hypocholesterolemia Endocrinology chemistry Kidney Failure Chronic Serum low density lipoprotein lipids (amino acids peptides and proteins) Female Original Article Hydroxymethylglutaryl-CoA Reductase Inhibitors business Risk assessment Biomarkers |
| Zdroj: | The Korean Journal of Internal Medicine |
| ISSN: | 2005-6648 |
| Popis: | Background/Aims The clinical implications of hypocholesterolemia have not been well studied, although some studies have revealed an association between hypocholesterolemia and intracerebral hemorrhage (ICH). We evaluated the clinical characteristics of subjects with very low-density lipoprotein cholesterol (LDL-C) and compared the risk for ICH using various clinical parameters. Methods Using hospital records, we evaluated the clinical characteristics of subjects with LDL-C levels ≤ 40 mg/dL (very low LDL-C group). We also evaluated the risk for ICH in this very low LDL-C group and in subjects with low LDL-C ≤ 70 mg/dL (low LDL-C group). Results Among 34,415 subjects who presented at the laboratory for serum LDL-C measurements, 250 subjects had a very low serum LDL-C level (≤ 40 mg/dL). About half of the subjects were statin users; the very low LDL levels in the other subjects were likely attributable to alcohol consumption or a various chronic illness such as liver disease or end-stage renal disease (ESRD). ICH occurred in three subjects with very low LDL-C, all of whom had no history of statin use. ESRD tended to be associated with ICH in subjects with serum LDL-C ≤ 70 mg/dL. Conclusions About 1% of the subjects whose LDL-C was measured in the hospital had a LDL-C level ≤ 40 mg/dL, and about half of these subjects had no history of hypolipidemic therapy. ICH incidence was not related to LDL-C level or statin use. |
| Databáze: | OpenAIRE |
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