Familial influence on Parkinsonism in a rural area of Turkey (Kizilcaboluk-Denizli). A community-based case-control study

Autor: Huseyin Bagci, G. Ozan Çetin, Fatma Özdemir, Türker Şahiner, Peter Heutink, Füsun Düzcan, Vincenzo Bonifati, Mehmet Zencir
Přispěvatelé: Clinical Genetics
Rok vydání: 2003
Předmět:
Gerontology
Male
Rural Population
demography
age distribution
epidemiological data
environmental exposure
genetic identification
Aged
Aged
80 and over
Case-Control Studies
Cross-Sectional Studies
Environmental Pollutants/toxicity
Female
Genetic Predisposition to Disease/epidemiology/genetics
Genetics
Population/statistics & numerical data
Humans
Incidence
Life Style
Middle Aged
Parkinsonian Disorders/epidemiology/*genetics
Pesticides/toxicity
Risk Factors
Rural Population/*statistics & numerical data
Social Environment
Social Isolation
Socioeconomic Factors
genetic risk
Turkey (republic)
environmental factor
occupation
Family history
parkinsonism
familial disease
education.field_of_study
family history
Parkinsonism
adult
pathogenesis
article
Family aggregation
Case-control study
academic achievement
aged
female
Neurology
priority journal
Environmental Pollutants
alcohol consumption
sex difference
Population
prevalence
rural area
smoking
Parkinsonian Disorders
medicine
controlled study
Genetic Predisposition to Disease
human
levodopa
Pesticides
education
pesticide
business.industry
questionnaire
disease association
population genetics
Odds ratio
case control study
medicine.disease
major clinical study
Confidence interval
Genetics
Population
confidence interval
Neurology (clinical)
Rural area
business
population research
head injury
Demography
Zdroj: Movement Disorders, 18(7), 799-830. John Wiley & Sons Inc.
ISSN: 1531-8257
0885-3185
DOI: 10.1002/mds.10440
Popis: This population-based study on parkinsonism in a genetically isolated community from a rural area of Turkey aimed to provide a selective evaluation of environmental and heritable risk factors. An increased prevalence of parkinsonism (4.1%) was detected in the village of Kizilcaboluk for people 65 years of age and older. This study included 36 patients with parkinsonism living in Kizilcaboluk and three times that number of age- and sex-matched people serving as controls. A questionnaire including demographic data, family history, education, occupation, data on exposures to pesticides, smoking, alcohol intake, and head trauma was administered. We found a significant association of parkinsonism cases with a positive family history in first-degree relatives (odds ratio [OR], 7.48; 95% confidence interval [CI], 2.52-22.17; P < 0.0001) and with pesticide exposure (OR, 2.96; 95% CI, 1.31-6.69; P = 0.015) compared to the control subjects. The value of genetically isolated populations for the identification of genetic risk factors for common and complex disorders has gained much attention recently because the genetic make-up of these populations is likely to be less complex than that of the general population and our findings should prompt investigations to the nature of a familial aggregation of parkinsonism in this population. © 2003 Movement Disorder Society.
Databáze: OpenAIRE
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