Infectivity of titered doses of simian immunodeficiency virus clone E11S inoculated intravenously into rhesus macaques (Macaca mulatta)
| Autor: | J L Ribas, Stanford T. Roodman, Gerald A. Eddy, W B Knott, Raoul E. Benveniste, Mark G. Lewis, R W Hill |
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| Rok vydání: | 1994 |
| Předmět: |
Serial dilution
viruses Immunoblotting Molecular Sequence Data Simian Acquired Immunodeficiency Syndrome Biology Antibodies Viral medicine.disease_cause Polymerase Chain Reaction Sensitivity and Specificity Macaque Virus biology.animal medicine Animals DNA Primers Infectivity Base Sequence General Veterinary Infectious dose Macaca nemestrina Simian immunodeficiency virus Macaca mulatta Virology biology.protein Simian Immunodeficiency Virus Animal Science and Zoology Antibody |
| Zdroj: | Journal of Medical Primatology. 23:83-88 |
| ISSN: | 0047-2565 |
| DOI: | 10.1111/j.1600-0684.1994.tb00106.x |
| Popis: | The macaque infectious dose (MID) of a single-cell clone of simian immunodeficiency virus isolated from a pig-tailed macaque (SIV/Mne clone E11S) was determined in rhesus macaques (Macaca mulatta). Twenty-one macaques were inoculated with 10-fold dilutions of the virus stock (three or four animals per dose). The virologic and clinical status of these animals was monitored for 26 weeks. The 25% MID (MID25) occurred at a 10(5)-fold dilution of the viral stock. |
| Databáze: | OpenAIRE |
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