The Evaluation of Serum Pentraxin-3 and High-Sensitivity C-Reactive Protein Levels in Patients with Acute Attack of COPD
| Autor: | Meftun Unsal, Mehmet Ekiz, Latif Duran, Türker Yardan, Celal Kati, Abdulkerim Bedir, Suna Turkeli |
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| Přispěvatelé: | Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Acil Tıp Ana Bilim Dalı, Ekiz, Mehmet, Ondokuz Mayıs Üniversitesi |
| Rok vydání: | 2016 |
| Předmět: |
Acute Exacerbations
Adult Male medicine.medical_specialty Exacerbation inflammatory mediators Inflammation Disease Gastroenterology General Biochemistry Genetics and Molecular Biology Pulmonary function testing high-sensitivity C-reactive protein (hs-CRP) FEV1/FVC ratio Pulmonary Disease Chronic Obstructive Internal medicine medicine Humans Intensive care medicine Chronic Obstructive Pulmonary (COPD) pentraxin 3 (PTX3) Lung acute exacerbations Aged Aged 80 and over COPD biology business.industry C-reactive protein PTX3 Middle Aged medicine.disease respiratory tract diseases Serum Amyloid P-Component C-Reactive Protein inflammatory Mediators biology.protein Pentraxin 3 (PTX3) Female medicine.symptom business High-Sensitivity C-Reactive Protein (hs-CRP) |
| Zdroj: | Clinical laboratory. 61(12) |
| ISSN: | 1433-6510 |
| Popis: | WOS: 000367771200014 PubMed: 26882815 Background: Acute exacerbations of chronic obstructive pulmonary disease (COPD) are characterized by the release of inflammatory mediators. The aim of this study was to compare serum levels of pentraxin 3 (PTX3) and high-sensitivity C-reactive protein (hs-CRP) in patients with acute exacerbations of COPD with those of a healthy control group. Methods: The study included 107 men and 19 women, with mean age of 66.5 (32 - 87) years who were diagnosed with acute COPD exacerbations and 48 healthy individuals as a control group. The serum PTX3 and hs-CRP levels were measured and pulmonary function tests were performed. Results: The mean serum level of the hs-CRP was 39.56 mg/L (10.10 - 262), and it was higher in the COPD group than in the control group (p < 0.0001). The hs-CRP levels increased in accordance with the severity of the COPD (p < 0.0001). The serum PTX3 level was 0.52 pcg/dL (0.42 - 0.56) in acute exacerbations. There was a correlation between the PTX3 levels and the pulmonary function tests, including FEV1, FVC, and FEV1/FVC (r = 0.317, p < 0.001; r = 0.385, p < 0.0001, and r = 0.248, p = 0.001, respectively). Conclusions: The short pentraxin hs-CRP is elevated in COPD patients with acute exacerbations and correlates with the severity of the disease compared with the long pentraxin PTX3. These results support the idea that hs-CRP can be used as an earlier determinant of inflammation in COPD acute exacerbations and that PTX3 cannot be used as a marker of acute exacerbation and disease severity. Ondokuz Mayis University Research FundOndokuz Mayis University [PYO. TIP.1901.11.005] This study was supported by grants from the Ondokuz Mayis University Research Fund, project number PYO. TIP.1901.11.005. |
| Databáze: | OpenAIRE |
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