Tumor imaging with carbon-11 labeled alpha-aminoisobutyric acid (AIB) in a patient with advanced malignant melanoma
| Autor: | Richard S. Benua, Peter S. Conti, Peter P. Sordillo, John S. Laughlin, Rodney E. Bigler, Bernard Schmall, James R. Bading |
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| Rok vydání: | 1986 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Aminoisobutyric Acids Lung Neoplasms Skin Neoplasms medicine.medical_treatment Hilum (biology) Mediastinal Neoplasms medicine Humans Radiology Nuclear Medicine and imaging Carbon Radioisotopes Radionuclide Imaging Melanoma chemistry.chemical_classification Tumor imaging Chemotherapy Lung business.industry Liver Neoplasms General Medicine medicine.disease Amino acid Alpha-aminoisobutyric acid Metastatic malignant melanoma medicine.anatomical_structure chemistry business |
| Zdroj: | European Journal of Nuclear Medicine. 12:353-356 |
| ISSN: | 1619-7089 0340-6997 |
| DOI: | 10.1007/bf00263819 |
| Popis: | A 29 year-old-man presenting with advanced metastatic malignant melanoma was successfully imaged using carbon-11 (11C) labeled alpha-aminoisobutyric acid (AIB), a synthetic, non-metabolized amino acid transported into viable cells by the A-type, or alanine-preferring, amino acid transport system. Tumor located in the hilum of the lung was well visualized with 11C-AIB prior to chemotherapy. A gallium image with liver subtraction using 99mTc-sulfur colloid demonstrated regions of increased activity in liver which correlated with regions of increased activity on the 11C-AIB liver image. |
| Databáze: | OpenAIRE |
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