Marked deciliation and insufficient secretory modification of endometrial surface during treatment with a new progestogen-estrogen combination
| Autor: | Cavalli G, A. Baglioni, G.L. Taccagni, Maurizio Marchini, Luigi Fedele |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.drug_class medicine.medical_treatment media_common.quotation_subject Uterus Endometrium Ethinyl Estradiol Ethinylestradiol Internal medicine medicine Humans Cilia Cyproterone Cyproterone Acetate Menstrual cycle Menstrual Cycle media_common Progestogen business.industry Obstetrics and Gynecology Histology Androgen Antagonists Drug Combinations medicine.anatomical_structure Endocrinology Reproductive Medicine Estrogen In utero Microscopy Electron Scanning Female business medicine.drug |
| Zdroj: | Contraception. 35(5) |
| ISSN: | 0010-7824 |
| Popis: | Endometrial modifications induced by SHB 209 AE, a new progestogen-estrogen combination, was investigated using scanning and transmission electron microscopy, in order to demonstrate specific variations of the endometrial surface and if these contribute to the contraceptive effects of the preparation. Endometrial biopsies were performed in 27 volunteers who had taken SHB 209 AE during the preceding 3 months. Endometrial biopsies of 15 normomenstruating volunteers were used as controls. Each fragment was subdivided for scanning and transmission electron microscopy examination. The ciliated cells were always significantly fewer in the various phases of the treatment cycle than in the control endometria although, as in the controls, their number and ratio with nonciliated cells was greater mid-way through the cycle. Ciliogenesis was always notably delayed compared to the normal endometria during the different treatment cycle phases. Secretory modifications appeared prematurely but remained incomplete through the treatment cycle. These modifications caused total and characteristic alterations of the mucosal architecture and cellular maturation that comprised the implantation phase. |
| Databáze: | OpenAIRE |
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