Unbalanced jumping translocation involving 3q in myeloproliferative disease
| Autor: | Donald Hull, Peter McGrattan, Mervyn Humphreys |
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| Rok vydání: | 2008 |
| Předmět: |
Cancer Research
medicine.medical_specialty Clone (cell biology) Chromosomal translocation Biology medicine.disease_cause Translocation Genetic Jumping Myeloproliferative Disorders Internal medicine Bronchopneumonia medicine Humans Hydroxyurea Aged 80 and over Genetics Acute leukemia Hematology Chromosomes Human Pair 10 Chromosome General Medicine Interspersed Repetitive Sequences Oncology Chromosome 3 Immunology Female Chromosomes Human Pair 3 Chromosomes Human Pair 8 |
| Zdroj: | Medical Oncology. 26:251-255 |
| ISSN: | 1559-131X 1357-0560 |
| DOI: | 10.1007/s12032-008-9074-y |
| Popis: | An 87-year-old woman was diagnosed with unclassified myeloproliferative disease having an acquired jumping translocation with the long arm of chromosome 3 translocating to the short arm telomeric region of chromosome 8 (major clone) and the long arm telomeric region of chromosome 10 (minor clone). Each abnormal clone was also associated with an extra copy of chromosome 8. Although there was no evidence of transformation to an acute leukemia, the patient deteriorated until her demise 7 months after disease presentation. There have been fewer than 70 cases of acquired jumping translocations reported in the literature. To our knowledge, this is the first acquired jumping translocation case to be reported in a patient with myeloproliferative disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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