Investigation of anti-Müllerian hormone concentrations in relation to natural conception rate and time to pregnancy

Autor: J.G. Bentzen, Kathrine Birch Petersen, Linda Hilsted, Helene Westring Hvidman, Anne-Sofie Korsholm, Anders Nyboe Andersen
Rok vydání: 2017
Předmět:
Zdroj: Reproductive biomedicine online. 36(5)
ISSN: 1472-6491
2008-2010
Popis: The objectives of this study were to investigate whether anti-Müllerian hormone (AMH) concentrations can predict pregnancy rates and time to pregnancy (TTP) in women attempting to conceive naturally/having an unplanned conception, and whether there is a lower AMH threshold compatible with natural conception. This prospective cohort study included 260 women aged 25-42 years in two subcohorts: (A) healthcare workers at Rigshospitalet (2008-2010), and (B) women consulting the Fertility Assessment and Counselling Clinic (2011-2014), Rigshospitalet, Denmark. Pregnancy rates and TTP at 2-year follow-up were stratified into AMH groups: low:9.5 pmol/l, intermediate: 9.5-33 pmol/l, high:33 pmol/l. Pregnancy rates increased with increasing AMH: 60.1% (low) versus 70.0% (intermediate) versus 78.3% (high) (P = 0.03). The highest pregnancy rate (84.1%) was seen in regular cycling women with high AMH. TTP was reduced in women with high AMH compared with intermediate or low AMH (stepwise trend test P = 0.01). Natural conceptions were observed with AMH concentrations down to 1.2 pmol/l. In conclusion, high AMH, especially in ovulatory women, was associated with higher pregnancy rates. Nonetheless, TTP reflected a large variation in fecundity within similar AMH concentrations and natural conceptions occurred with AMH down to 1.2 pmol/l.
Databáze: OpenAIRE
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