Survival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus
| Autor: | Aaron R. Mangold, Heidi E. Kosiorek, Nina J. Karlin, Curtiss B. Cook, Sophia A. Ederaine, Jamison A. Harvey, Matthew R. Buras, Johanny Lopez Dominguez, Kyle E Coppola |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology squamous cell carcinoma medicine.medical_specialty Cell outcomes research 03 medical and health sciences endocrinology 0302 clinical medicine Internal medicine Diabetes mellitus medicine cancer In patient Basal cell Glycemic diabetes business.industry Cancer medicine.disease stomatognathic diseases 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis glycemic control Outcomes research business Biotechnology Research Article |
| Zdroj: | Future Science OA |
| ISSN: | 2056-5623 |
| Popis: | Aim: This study examined the impact of diabetes mellitus (DM) on survival in squamous cell carcinoma (SCC) patients, and the impact of SCC on glycemic control. Materials & methods: Patients with newly diagnosed SCC with and without DM were matched 1:1 (2007–2017). Overall survival and recurrence-free survival were estimated using the Kaplan–Meier method. Hemoglobin A1c (HbA1c) and glucose level during the year following cancer diagnosis were compared using mixed models. Results: HbA1c decreased over time in DM patients (p = 0.04). The 5-year overall survival was 61% in DM patients, compared with 78% in patients without DM (p = 0.004). Conclusion: The presence of co-existing DM adversely impacted survival in patients with SCC. SCC did not affect glycemic control. Lay abstract The objective of this study was to identify the effect of diabetes mellitus (DM) on survival of patients with squamous cell carcinoma (SCC) and to determine whether SCC and its treatment affected glycemic control. We used an institutional cancer registry to identify 190 patients with SCC and grouped them by the presence (n = 95) or absence (n = 95) of DM. Patients were matched by age and year of SCC diagnosis. For individuals with SCC, DM did decrease survival rates, and the diagnosis of SCC did not affect glycemic control. |
| Databáze: | OpenAIRE |
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