Immediate and longitudinal effects of maltreatment on systemic inflammation in young children
Autor: | Karin de Punder, Sibylle Winter, Elisabeth B. Binder, Sonja Entringer, Katja Dittrich, Christine Heim, Gergana Karaboycheva, Claudia Buss, Judith Overfeld |
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Rok vydání: | 2020 |
Předmět: |
Male
Pediatrics medicine.medical_specialty Population Psychological intervention Early life stress Systemic inflammation medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Developmental and Educational Psychology medicine Humans Psychological stress Child Abuse Child education Adverse Childhood Experiences Retrospective Studies Inflammation education.field_of_study biology C-reactive protein Infant 030227 psychiatry Psychiatry and Mental health Young age C-Reactive Protein Cross-Sectional Studies Child Preschool biology.protein Female medicine.symptom Psychology 030217 neurology & neurosurgery |
Zdroj: | Development and Psychopathology. 32:1725-1731 |
ISSN: | 1469-2198 0954-5794 |
Popis: | Exposure to child maltreatment increases the risk for psychiatric and physical diseases. Inflammation has been proposed as a mechanism through which early adverse experiences become biologically embedded. However, most studies providing evidence for the link between early adverse exposures and inflammation have been retrospective or cross-sectional in design, or did not assess inflammation immediately after maltreatment in young children. In the present study we investigated the association between childhood maltreatment and salivary C-reactive protein (CRP) concentrations in a population of N = 173 children, 3–5 years of age, who were recruited in the immediate aftermath of maltreatment and followed-up longitudinally every 6 months over a period of 2 years. We found that the association between maltreatment and CRP concentrations was significantly moderated by child sex, such that in girls, CRP concentrations were higher in the maltreated compared to the control group, and this difference was stable across the 2-year follow-up-period, while in boys, there was no association between maltreatment and CRP. Our findings suggest that the effect of maltreatment on inflammation may already emerge right after exposure at a very young age in girls and manifest over time. Our study provides important evidence for the development of personalized, early interventions strategies targeting the early-life period. |
Databáze: | OpenAIRE |
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