Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen
| Autor: | Daniëlle Hijdra, Henk C. Hoogsteden, Hamida Hammad, Monique Willart, Nanda Vos, Bart N. Lambrecht, Hendrik Jan de Heer, Thomas Soullié |
|---|---|
| Přispěvatelé: | Pulmonary Medicine, Otorhinolaryngology and Head and Neck Surgery |
| Rok vydání: | 2004 |
| Předmět: |
regulatory T cell
Adoptive cell transfer Myeloid Ovalbumin Regulatory T cell T-Lymphocytes medicine.medical_treatment T cell Immunology Mice Transgenic Immunoglobulin E Article Mice Antigen T-Lymphocyte Subsets Administration Inhalation Respiratory Hypersensitivity medicine Animals Immunology and Allergy Antigens Lung Sensitization Mice Inbred BALB C tolerance biology business.industry hemic and immune systems Dendritic Cells asthma respiratory tract diseases medicine.anatomical_structure Cytokine plasmacytoid dendritic cells biology.protein mucosal immunity business |
| Zdroj: | The Journal of Experimental Medicine Journal of Experimental Medicine, 200(1), 89-98. Rockefeller University Press |
| ISSN: | 0022-1007 |
| Popis: | Tolerance is the usual outcome of inhalation of harmless antigen, yet T helper (Th) type 2 cell sensitization to inhaled allergens induced by dendritic cells (DCs) is common in atopic asthma. Here, we show that both myeloid (m) and plasmacytoid (p) DCs take up inhaled antigen in the lung and present it in an immunogenic or tolerogenic form to draining node T cells. Strikingly, depletion of pDCs during inhalation of normally inert antigen led to immunoglobulin E sensitization, airway eosinophilia, goblet cell hyperplasia, and Th2 cell cytokine production, cardinal features of asthma. Furthermore, adoptive transfer of pDCs before sensitization prevented disease in a mouse asthma model. On a functional level, pDCs did not induce T cell division but suppressed the generation of effector T cells induced by mDCs. These studies show that pDCs provide intrinsic protection against inflammatory responses to harmless antigen. Therapies exploiting pDC function might be clinically effective in preventing the development of asthma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|