Clinical significance of quantitative assessment of right ventricular glucose metabolism in patients with heart failure with reduced ejection fraction

Autor: Yen-Wen Wu, Szu-Ying Tsai, Chien-Lin Lee, Shan-Hui Huang, Shan-Ying Wang, Jung-Cheng Hsu, Hao-Yuan Tsai, Kuan-Ming Chiu, Yu-Chien Shiau, Heng-Hsu Lin, Chung-Ming Tu
Rok vydání: 2019
Předmět:
Zdroj: European Journal of Nuclear Medicine and Molecular Imaging. 46:2601-2609
ISSN: 1619-7089
1619-7070
Popis: Dynamic 18F-fluorodeoxyglucose (FDG) PET can be used to quantitatively assess the rate of myocardial glucose uptake (MRGlu). The aim of this study was to evaluate the clinical significance and prognostic value of right ventricular (RV) MRGlu in patients with coronary artery disease and heart failure with reduced ejection fraction. Patients with left ventricular ejection fraction (LVEF) ≤ 40% were consecutively enrolled for FDG PET between November 2012 and May 2017. Global LV and RV MRGlu (μmol/min/100 g) were analyzed. Outcome events were independently assessed using electronic medical records to determine hospitalization for revascularization, new-onset ischemic events, heart failure, cardiovascular, and all-cause death. Differences between LV and RV MRGlu and associations with clinical characteristics and echocardiographic data were evaluated. Associations among FDG PET findings and outcomes were analyzed using Kaplan-Meier survival analysis. Seventy-five patients (mean age 62.2 ± 12.7 years, male 85.3%, LVEF 19.3 ± 8.6%) were included for analysis. The mean glucose utilization ratio of RV-to-LV (RV/LV MRGlu) was 89.5 ± 264.9% (r = 0.77, p
Databáze: OpenAIRE
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