Speckled brain lesions in Incontinentia Pigmenti patients with acquired brain syndromes
| Autor: | Pravin Rr, Louise Hartley, CC Tchoyoson Lim, Tong Hong Yeo, Mark Jean Aan Koh, Catherine Douch, Angeline H M Lai, Terrence Thomas |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Adolescent Encephalopathy medicine.disease_cause Transverse myelitis Virus White matter 03 medical and health sciences 0302 clinical medicine Seizures 030225 pediatrics medicine Influenza A virus Humans Incontinentia Pigmenti Child Brain Diseases medicine.diagnostic_test business.industry Infant Newborn Brain Infant Magnetic resonance imaging General Medicine Incontinentia pigmenti medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Child Preschool Pediatrics Perinatology and Child Health Female Neurology (clinical) business 030217 neurology & neurosurgery Encephalitis |
| Zdroj: | European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. 33 |
| ISSN: | 1532-2130 |
| Popis: | Incontinentia Pigmenti (IP) is a neurocutaneous syndrome, with malformations of cortical development and neurodevelopmental delay in some patients. Neonates with IP may develop acute encephalopathy with multifocal ischemic brain lesions with a speckled pattern on diffusion-weighted magnetic resonance imaging (MRI). We observed a similar MRI pattern in 4 female patients with IP who presented with childhood acute encephalopathy syndromes. These patients, aged 9 days to 13 years old, had acute neonatal encephalitis, Influenza A virus related acute necrotizing encephalopathy (ANE) of childhood, Influenza B virus related acute encephalopathy with biphasic seizures and late restricted diffusion (AESD) and acute disseminated encephalitis (ADEM) with transverse myelitis (TM). These lesions could possibly reflect the white matter changes in IP patients with encephalopathy. |
| Databáze: | OpenAIRE |
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