Urinary NOx:creatinine ratios during gluten challenge in children with celiac disease
| Autor: | I. M. Y. Bovee-Oudenhoven, W. A. Kors, E. A. Van Straaten, R. Van Der Meer, Linda Koster-Kamphuis, J. E. A. R. De Schrijver, P Ph Forget |
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| Přispěvatelé: | Kindergeneeskunde, RS: NUTRIM School of Nutrition and Translational Research in Metabolism |
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Glutens Urinary system Urine Nitric Oxide Gastroenterology Coeliac disease chemistry.chemical_compound Immunopathology Internal medicine medicine Humans Enteropathy Child Nitrites chemistry.chemical_classification Creatinine Nitrates business.industry nutritional and metabolic diseases medicine.disease Gluten Pathophysiology digestive system diseases Renal disorders [UMCN 5.4] Celiac Disease Endocrinology chemistry Child Preschool Pediatrics Perinatology and Child Health Female Nitric Oxide Synthase business |
| Zdroj: | Journal of Pediatric Gastroenterology and Nutrition, 36(3), 372-375. LIPPINCOTT WILLIAMS & WILKINS Journal of Pediatric Gastroenterology and Nutrition, 36, 3, pp. 372-5 Journal of Pediatric Gastroenterology and Nutrition, 36, 372-5 |
| ISSN: | 0277-2116 |
| Popis: | Urinary NOx:creatinine ratios during gluten challenge in children with celiac disease.Koster-Kamphuis L, van Straaten EA, Kors WA, De Schrijver JE, Bovee-Oudenhoven IM, vandDer Meer R, Forget PP.Department of Pediatrics, University Hospital, Maastricht, The Netherlands.OBJECTIVES: Celiac disease is a gluten-induced small bowel enteropathy. Inflammation is known to be associated with enhanced nitric oxide (NO) production. An increase in urinary nitrate and nitrite (NOx) reflects increased NO production. The urinary NOx:creatinine ratio can be used as an indicator of the endogenous NO production. The aim of the study was to determine whether the urinary NOx:creatinine ratio of celiac disease patients increases during gluten challenge. METHODS: The authors studied 20 patients with unconfirmed celiac disease who had been following a gluten-free diet for at least 1 year. These patients underwent an 80-day gluten challenge. Urinary samples were obtained before and 10, 20, 40, and 80 days after starting the gluten challenge. The Griess reagent method was used for measuring urinary NOx. RESULTS: Gluten challenge confirmed the diagnosis of celiac disease in 15 of 20 patients. The NOx:creatinine ratios (mmol:mmol) of the biopsy-confirmed celiac disease patients were significantly higher than those of the unconfirmed celiac disease patients (0.67 vs. 0.17 on day 10; 0.78 vs. 0.15 on day 20; 0.85 vs. 0.25 on day 40; and 0.85 vs. 0.17 on day 80). CONCLUSIONS: Gluten challenge resulted in an increased urinary NOx:creatinine ratio in patients with biopsy-confirmed celiac disease. The NOx:creatinine ratio could be useful for the serial evaluation of disease activity |
| Databáze: | OpenAIRE |
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