Psoriasis and skin pain: real-life effectiveness of calcipotriol plus betamethasone dipropionate in aerosol foam formulation
| Autor: | G. Lodi, Anna Balato, V. Dente, Teresa Cirillo, Lucia Gallo, Paola Di Caterino, Matteo Megna, R. Mozzillo |
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| Přispěvatelé: | Gallo, L, Megna, M, Cirillo, T, Caterino, P, Lodi, G, Mozzillo, R, Dente, V, Balato, A. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pain Threshold medicine.medical_specialty Administration Topical Anti-Inflammatory Agents Betamethasone dipropionate Pain Dermatology Betamethasone Severity of Illness Index 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Quality of life Calcitriol Psoriasis Area and Severity Index Psoriasis Threshold of pain Medicine Humans Prospective Studies Calcipotriol Aerosol Foam Aged Pain Measurement Aerosols integumentary system business.industry Middle Aged medicine.disease Hand Drug Combinations Infectious Diseases chemistry 030220 oncology & carcinogenesis Female Dermatologic Agents business Palmar Region medicine.drug |
| Popis: | Background/objective: Although 40% of psoriasis patients reported skin pain, this symptom is often underestimated. A new formula of calcipotriol plus betamethasone dipropionate (Cal/BD) has been recently approved for psoriasis treatment. Therefore, we aimed to evaluate the efficacy of Cal/BD aerosol foam on skin pain of patients with plaque psoriasis. Methods: A real-life 4-week prospective, open study on Cal/BD aerosol foam (not compared to vehicle or emollient cream) was performed in adult psoriasis patients attending three Dermatology units located in Campania region, Italy, between March and October 2018. Inclusion criteria were a history of skin pain over the last week and psoriatic involvement of the palmar area. Before (t0) and after a course of once daily application of Cal/BD aerosol foam for 4 weeks (t1), the following items were evaluated: Psoriasis Area and Severity Index (PASI), Physician Global Assessment (PGA) index of target plaque on palmar region, subjective skin pain features through Pain Qualities Assessment Scale questionnaire and skin pain threshold measured by pressure digital algometer at palmar psoriatic plaques. Results: Seventy-five patients (43 male, mean age of 43.2 years) were enrolled. After 4 weeks of therapy with Cal/BD aerosol foam, a significant improvement in both PASI (mean: 6.5 ± 2.1 at t0 vs. 2.3 ± 1.6 at t1) and palmar plaques PGA (mean: 3.6 at t0 vs. 1.7 at t1) was observed (P < 0.001). The mean intensity score of skin pain decreased from 7.6 to 1.3 (P < 0.001); among skin pain qualities, intense, sensible, aching and unpleasant showed the highest rate of reduction (t0-t1: 6.3, 6.3, 6.1 and 5.8, respectively). Pain threshold of palmar skin lesions increased at t1. Conclusions: Our real-life study suggested that Cal/BD aerosol foam may represent a valid topical anti-psoriatic treatment, not only improving skin lesions, but also relieving cutaneous pain, thus contributing to ameliorate patients' quality of life. |
| Databáze: | OpenAIRE |
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