A novel cytotoxic flavonoid C-glycoside from premna fulva
| Autor: | Sheng-Nan Yan, Ting-Ting Zhang, Hai-Jiang Zhang, Hong Wang, Kuiwu Wang, Bin Wu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
C glycosides Traditional medicine biology 010405 organic chemistry Verbenaceae Organic Chemistry Flavonoid Glycoside Plant Science biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry Phytochemical Premna fulva |
| Zdroj: | Natural Product Research. 35:945-950 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2019.1613393 |
| Popis: | Premna fulva Craib, locally known as “Zhangu” in China, is a kind of traditional medicinal plant. A phytochemical investigation on this plant led to the isolation of a novel flavonoid glycoside along with three known analogues. The chemical structure of the new compound was determined by spectral and chemical analysis as apigenin 8-C-β-D-xylopyranoside (1). Compound 1 showed weak inhibitory activities in vitro against to four tumor cell lines (HL-60, Bcap37, SMMC7721, and P388) with IC50 values of 12.58, 19.31, 31.02, and 48.19 μg/mL, respectively. The result might be helpful to explain the application of P. fulva in Traditional Chinese Medicine. |
| Databáze: | OpenAIRE |
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