An integrative model on the role of DMBT1 in epithelial cancer
| Autor: | Stefan Wiemann, Uffe Holmskov, Herwart F. Otto, Inge Krebs, Hanna Müller, Jens Madsen, Jan Mollenhauer, Gaby Kollender, Burkhard Helmke, Annemarie Poustka |
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| Rok vydání: | 2002 |
| Předmět: |
Cancer Research
Tumor suppressor gene Molecular Sequence Data Down-Regulation Loss of Heterozygosity Receptors Cell Surface Minisatellite Repeats Biology medicine.disease_cause Loss of heterozygosity Tandem repeat Calcium-binding protein medicine Tumor Cells Cultured Humans Amino Acid Sequence Neoplasms Glandular and Epithelial Gene Genetics Regulation of gene expression Tumor Suppressor Proteins Mucin Calcium-Binding Proteins Chromosome Mapping DNA-Binding Proteins Gene Expression Regulation Neoplastic Oncology Agglutinins Organ Specificity Cancer research Carcinoma Squamous Cell Carcinogenesis |
| Zdroj: | Mollenhauer, J, Helmke, B, Müller, H, Kollender, G, Krebs, I, Wiemann, S, Holmskov, U, Madsen, J, Otto, H F & Poustka, A 2002, ' An integrative model on the role of DMBT1 in epithelial cancer. ', Cancer Detection and Prevention, vol. 26, no. 4, pp. 266-74 . https://doi.org/10.1016/s0361-090x(02)00094-6 |
| ISSN: | 0361-090X |
| Popis: | Udgivelsesdato: 2002-null The gene, deleted in malignant brain tumors 1 (DMBT1), has been proposed to play a role in brain and epithelial cancer, but shows unusual features for a classical tumor suppressor gene. We have proposed that its presumptive dual function in protection and differentiation is of importance to understand its role in cancer. To gain insights into its role in tumorigenesis, we conducted a comprehensive study on DMBT1 mutations, expression and location. Twenty-one out of 44 tumors showed variable numbers of tandem repeats (VNTRs) due to genetic polymorphism of DMBT1, whereas 11 out of 44 tumors displayed presumable mutations. However, none of the alterations would be predicted to lead to a complete inactivation of the gene. DMBT1 is mucin-like and shows tissue-specific expression and secretion, pointing to a function in the protection of monolayered epithelia and to an additional function in the differentiation of multilayered epithelia. The expression patterns in carcinomas arising from the respective structures support this view. Accepting this functional dualism gives rise to an initial model on the role of DMBT1 in epithelial cancer. |
| Databáze: | OpenAIRE |
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