Evolutionary and Ecological Drivers Shape the Emergence and Extinction of Foot-and-Mouth Disease Virus Lineages
| Autor: | Mehdi Khalaj, Ünal Parlak, Donald P. King, Ghulam Ziay, Darab Abdollahi, Pelin Tuncer-Göktuna, Seyed Mohsen Dastoor, Muhammad Afzal, Boris Gelman, Sharon Karniely, Manzoor Hussain, Alexey Scherbakov, Ehtisham-ul-Haq Khan, Reza Hassanzadeh, Luca Ferretti, Nick J. Knowles, Jemma Wadsworth, Antonello Di Nardo, Valerie Mioulet, Fuat Özyörük |
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| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Asia animal diseases viruses Metapopulation phylogeography Biology AcademicSubjects/SCI01180 Serogroup molecular epidemiology 010603 evolutionary biology 01 natural sciences Virus 03 medical and health sciences Genetics Animals Central Molecular Biology Discoveries Ecology Evolution Behavior and Systematics 030304 developmental biology 0303 health sciences Extinction Host (biology) Ecology AcademicSubjects/SCI01130 phylodynamics biology.organism_classification Phylogeography Viral phylodynamics Foot-and-Mouth Disease Virus Foot-and-Mouth Disease Threatened species Foot-and-mouth disease virus and Southern Asia Western |
| Zdroj: | Molecular Biology and Evolution |
| ISSN: | 1537-1719 |
| Popis: | Livestock farming across the world is constantly threatened by the evolutionary turnover of foot-and-mouth disease virus (FMDV) strains in endemic systems, the underlying dynamics of which remain to be elucidated. Here, we map the eco-evolutionary landscape of cocirculating FMDV lineages within an important endemic virus pool encompassing Western, Central, and parts of Southern Asia, reconstructing the evolutionary history and spatial dynamics over the last 20 years that shape the current epidemiological situation. We demonstrate that new FMDV variants periodically emerge from Southern Asia, precipitating waves of virus incursions that systematically travel in a westerly direction. We evidence how metapopulation dynamics drive the emergence and extinction of spatially structured virus populations, and how transmission in different host species regulates the evolutionary space of virus serotypes. Our work provides the first integrative framework that defines coevolutionary signatures of FMDV in regional contexts to help understand the complex interplay between virus phenotypes, host characteristics, and key epidemiological determinants of transmission that drive FMDV evolution in endemic settings. |
| Databáze: | OpenAIRE |
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