Treatment of port wine stains with photodynamic therapy, using pulsed dye laser as a Light Source, Compared With Pulsed dye laser alone: A pilot study
| Autor: | R.J. Barlow, Habib A. Kurwa, Alistair Robson, Alun V. Evans |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty Port wine medicine.medical_treatment Port-Wine Stain Pilot Projects Photodynamic therapy Dermatology Light source stomatognathic system Ophthalmology medicine Humans Laser Coagulation Photosensitizing Agents Dye laser business.industry Significant difference Port-wine stain Aminolevulinic Acid medicine.disease Treatment Outcome Photochemotherapy Female Surgery Thermal damage business Laser coagulation |
| Zdroj: | Lasers in Surgery and Medicine. 36:266-269 |
| ISSN: | 1096-9101 0196-8092 |
| DOI: | 10.1002/lsm.20151 |
| Popis: | Background and Objectives Laser-induced photo thermal damage has been combined with photodynamic therapy (PDT) using a systemic photosensitiser to treat vascular lesions. The efficacy of PDT using systemic 5-aminolaevulinic acid (5-ALA) as the photosensitiser and pulsed dye laser (PDL) as the light source in port wine stains (PWS) is unknown. Study Designs/Materials and Methods We conducted an internally controlled pilot study comparing the efficacy of PDT using PDL as a light source, to PDL alone in the treatment of PWS. Results The PWS improved slightly in all patients but no significant difference was found between the three treatment arms in terms of lesional lightening or incidence and severity of side effects. Conclusions There was no evidence of increased efficacy of PDT using PDL as a light source compared to PDL alone. There was also no significant difference in adverse events. Further studies using different treatment regimens over longer periods of time may be warranted. © 2005 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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